Cancer Drug Resistance

A 3D Biomimetic System for Testing Anticancer Drugs Sensitivity.- Patient-Derived Breast Cancer Tissue Cultures for Anti-Endocrine Drug Assays.- Co-Culture of Two Different Cell Lines in a Two-Layer Microfluidic Device.- Generation and Culture of Organotypic Breast Carcinoma Spheroids for the Study of Drug Response in a 3D Microfluidic Device.- A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells.- Establishment of In Vivo Acquired Resistance to Chemotherapy via Individual Dose Escalation Treatment Regime.- A Label Retaining System to Capture Slow Cycling Cancer Cells.- A Fast and Furious Liquid Biopsy Assay to Monitor Targeted Therapy Resistance.- Assessment of Tumor Heterogeneity in High-Grade Serous Ovarian Cancer: Mass Cytometry to Understand the Complex Tumor Biology.- Analysis of Transcriptomic Data Generated from Drug Treated Cancer Cell Line.- Simultaneous Mapping of Enhancers and Enhancer Rearrangements with Paired-End H3K27ac ChIP-seq.- Identification of Drug Resistance Mechanisms using Genome-Wide CRISPR-Cas9 Screens.- RNA Sequencing Data Analysis on the Maser Platform and the Tag-Count Comparison-Graphical User Interface.- Dissecting the Epigenomic Driving Drug Resistance by ATAC-Seq.- Polygenomic Interrogation of Drug Resistance Genes.- Analysis of ER-phagy in Cancer Drug Resistance.- Drug Target Prediction using Context-Specific Metabolic Models Reconstructed from rFastcormics.