Naloxone, Flumazenil and Dantrolene as Antidotes

This volume describes an international project to evaluate the use of antidotes and other agents used in the management of poisoned patients.

---

The first volume provides an introduction to the series and reviews three antidotes: naloxone, a specific opioid antagonist used in the treatment of opiate poisoning; flumazenil, used to reverse the sedative, anti-convulsant and muscle-relaxant effects of benzodiazepines; and dantrolene sodium, used in the treatment of malignant hyperpyrexia and hyperthermia, neuroleptic malignant syndrome and hypercatabolic syndrome. This important new series arises from a coordinated programme of the International Programme on Chemical Safety (IPCS) (ILO/UNEP/WHO) and the Commission of the European Communities (CEC) to evaluate the efficacy of and indications for clinical and field use of these antidotes and other agents to treat poisoning.