Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

Hiroshi Yamazaki has been Professor of the Laboratory of Drug Metabolism and Pharmacokinetics at Showa Pharmaceutical University, Tokyo, Japan since 2005. After receiving his BS and MS degrees from Gifu Pharmaceutical University and a PhD in Pharmaceutical Sciences from Osaka University in Japan, he trained as a post-doctoral fellow at Vanderbilt University School of Medicine, Nashville, TN, USA in 1994. He was recruited as an Associate Professor at Kanazawa University from Osaka Prefectural Institute of Public Health in 1998 and then an Associate Professor at Hokkaido University Graduate School of Pharmaceutical Sciences in 2001. Professor Yamazaki’s research has focused on cytochromes P450, flavin-containing monooxygenases, and simple pharmacokinetic modeling. His P450 papers cover a broad range of topics. He has authored over 500 original publications (http://orcid.org/0000-0002-1068-4261) with an h-index of 66 in Scopus (Author ID: 557193405959) . Professor Yamazaki is a member of several professional societies and editorial committees and was designated as one of the experts of Chemical Substance Assessment Groups (of the Food and Safety Commission of Japan, 2006-15). He is a recipient of the Japanese Society for the Study of Xenobiotics (JSSX) Award and Fellowship and was ex-JSSX President (2017-19) and Editor-in-Chief of Drug Metabolism and Pharmacokinetics (2014-17). Professor Yamazaki was the leading organizer of 19th International Conference on Cytochrome P450, in Tokyo, Japan in 2015.

Preface Hiroshi Yamazaki 1. Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future F. Peter Guengerich 2. Pharmacogenetics of the cytochromes P450: Selected pharmacological and toxicological aspects Ann K. Daly 3. Cytochromes P450 and metabolism of drugs and neurotoxins within the mammalian brain Marlaina R. Stocco and Rachel F. Tyndale 4. Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences Michele M. Skopec, James R. Halpert and M. Denise Dearing 5. Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology Jacqueline Wen Hui Leow, Lloyd Wei Tat Tang and Eric Chun Yong Chan 6. Biosynthesis using cytochrome P450 enzymes: Focus on synthesis of drug metabolites W. Griffith Humphreys 7. Use of engineered cytochrome P450s for accelerating drug discovery and development Raine E.S. Thomson, Stephlina A. D’Cunha, Martin A. Hayes and Elizabeth M.J. Gillam 8. Assessing cytochrome P450 function using genetically engineered mouse models Sarrah Hannon and Xinxin Ding 9. Expressions and functional activities of cytochrome P450 enzymes in human hepatocytes having sustainable reproducibility for in vitro phenotyping study Pamela Bachour-El Azzi, Christophe Chesné and Shotaro Uehara 10. Cytochrome P450s in chimeric mice with humanized liver Shotaro Uehara, Hiroshi Suemizu and Hiroshi Yamazaki 11. Polymorphic cytochromes P450 in non-human primates Yasuhiro Uno, Shotaro Uehara and Hiroshi Yamazaki 12. Cytochrome P450 enzymes in the pediatric population: Connecting knowledge on P450 expression with pediatric pharmacokinetics Chie Emoto and Trevor N. Johnson 13. Cytochrome P450 polymorphism: From evolution to clinical use Magnus Ingelman-Sundberg