Nanocarriers for Drug Delivery -

Nanocarriers for Drug Delivery

Concepts and Applications
Buch | Softcover
X, 347 Seiten
2022 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-63391-2 (ISBN)
181,89 inkl. MwSt
This book covers basic aspects of different nanoparticles, including type of materials, lipid, polymeric and inorganic structures, synthesis strategies, as well as the main physicochemical characterization techniques. Moreover, this book addresses applications for both treatment and diagnosis of diseases, highlighting in vitro and in vivo findings and clinical evaluation. The chapters highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy and functionalization of nanoparticles with a variety of moieties, including monoclonal antibodies for selective delivery, are discussed and illustrated with examples. Finally, the application of nanoparticles for drug delivery to cancer is reviewed considering toxicology and regulatory aspects.

lt;p>Josimar Eloy is a Professor at the Federal University of Ceará (UFC), in Fortaleza, Brazil, working in the area of pharmaceutical technology and nanotechnology. His current research involves the strategy of functionalization of drug nanocarriers for targeting, evaluated in models in vitro (cytotoxicity and cell uptake by flow cytometry and confocal microscopy) and in vivo, using xenograft models in mice for breast cancer and prostate cancer.

Polymeric Nanoparticles.- Lipid Nanocarriers.- Inorganic nanoparticles for biomedical applications.- Colloidal Disperse Systems: Microemulsions and Nanoemulsions.- Physicochemical characterization of drug nanocarrriers.- Targeting of drug nanocarriers.- Nanocarriers for oral drug delivery.- Nanocarriers of drugs for topical delivery.- Recent advances in nanocarriers used for selective gene silencing therapy.- Nanocarriers for the diagnosis and treatment of cancer.- Nanosystems comprising biocompatible polymers for the delivery of photoactive compounds in biomedical applications.- Toxicology of Nanoparticles.- Regulation of Nanotechnology-based Products Subject to Health Regulations: Application of Quality by Design (QbD) and Quality Risk Management (QRM).

Erscheinungsdatum
Reihe/Serie Nanomedicine and Nanotoxicology
Zusatzinfo X, 347 p. 55 illus., 44 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 551 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Technik Maschinenbau
Technik Umwelttechnik / Biotechnologie
Schlagworte Diagnosis of Cancer • Drugs • nanoparticles • nanotechnology • Pharmacy
ISBN-10 3-030-63391-8 / 3030633918
ISBN-13 978-3-030-63391-2 / 9783030633912
Zustand Neuware
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