Cancer and Aging
CRC Press (Verlag)
978-0-367-24825-3 (ISBN)
First published in 1990: The book examines the relationship between age and the development of cancer from different angles, with a comprehensive approach that has not been used previously. The multiple pathways at the cellular and tissue levels that can lead to a neoplastic growth are described in detail, explaining the variable delay between cancer initiation and the clinical manifestations. The time that elapses between exposure to the carcinogen and the clinical incidence of different neoplasiae is exemplified through a review of epidemiological studies with atomic bomb survivors and environment-related cancers. The developmental phenomena and the genetic determinants that may lead to or retard the progression of cancer through the life span of the organism are emphasized, illustrating the very dynamic processes that involve neoplastic growth where new variables are continuously created.
Alvaro Macieire-Coelho, M.D., D.Sc., is Research Director at the French National Institute of Health (INSERM) and Head of the Division for Cell Aging Research at the Department of Cell Biology, University of Paris. Bo Nordenskjold, M.D., Ph.D., is Professor of Oncology at the University of Linkoping, Linkoping, Sweden.
Part 1: Factors Influencing the Age Incidence of Cancer 1A: Developmental Cell and Tissue Determinants 1. Cancer and Aging at the Cellular Level 2. Age-Dependant Modifications of Connective Tissues, Possible Relationships to Tumor Growth and Metastasis Formation 3. Developmental Changes of the Mammary Gland in Relation to Mammary Tumor Development 4. Age and Immunity 5. Effects of Age on DNA Repair in Relation to Carcinogenesis 6. Reproductive and Hormonal Factors in Relation to Cancer Occurrence in the Breast, Prostate, Testis, Uterine Corpus, Uterine Cervix, and Thyroid Gland 7. Dehydropiandrosterone: A Naturally Occuring Steroid with Cancer Preventive Activity 1B: Genetic Diseases 8. Colorectal Cancer in Familial Poliposis Coli 9. Progeroid Syndromes and Cancer 1C: Time After Exposure to the Carcinogen 10. Late Radiation Effects in Atomic Bomb Survivors: A Review 11. Geographical Patterns of Cancer: Role of Environment Part 2: Cancer Incidence and Progression 12. Childhood Cancer – Incidence and Etiological Considerations 13. Testicular Cancer and Age 14. Hodgkins Disease 15. Relationship of Age to Cancer of the Cervix 16. Age at Breast Cancer Diagnosis as a Predictor of Subsequent Survival 17. Relationship between Age and the Incidence of Liver Metastases 18. The Effect of Aging on the Development and Progression of Cancer: From the Laboratory Animal Clinic
Erscheinungsdatum | 07.02.2022 |
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Reihe/Serie | Routledge Revivals |
Zusatzinfo | 41 Tables, black and white; 9 Halftones, black and white |
Verlagsort | London |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
ISBN-10 | 0-367-24825-5 / 0367248255 |
ISBN-13 | 978-0-367-24825-3 / 9780367248253 |
Zustand | Neuware |
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