CardioPulmonary Bypass

After finishing the Medicine Faculty of Istanbul University in 1990, Prof Kirali fulfilled MD, MSc medical mandatory service duty and began his residency training in Kosuyolu Heart and Research Hospital in 1992. Following 5 years of assistant education, he was in England and the USA for education and training in 1998. He performed his work mostly in the field of videoscopic and minimally invasive cardiac surgery, and he became a consultant cardiovascular surgeon in 1998, Assistance Professor in 1999, Associate Professor in 2002, and chief in 2005 at the same hospital. Over the last 20 years, he has focused his scientific interests on topics related to cardiovascular repairs requiring special experience. With his expertise in coronary artery surgery, minimal invasive cardiac surgery, valve repair, and aortic root surgery, he has established new methods for awake coronary bypass revascularization, new surgical approach for AVR during first and re-operations, aortic valve sparing procedure, and radiofrequency ablation. He is the pioneer of awake complete CABG with BIMA and has also developed a new aortotomy incision technique for all kinds of aortic valvular or subvalvular interventions during first and re-operations, which simplifies the procedure with/without aortic valve insertion. He has experience on cardiac failure during ECMO and developed a specific design for recovery. He has been the director of transplantation department since 2015. Prof. Joseph Coselli is the chief Professor of Surgery, of the Division of Cardiothoracic Surgery and the Executive vice-chair of Michael E. DeBakey Department of Surgery at Baylor College of Medicine, United States. He has specialized in the evaluation and treatment of aortic disease, including the aortic valve and root, the aortic arch, and the thoracoabdominal aorta, using open surgical and endovascular techniques. In 40 years of service, he has performed more than 10,500 aortic repairs, including more than 3700 repairs of thoracoabdominal aortic aneurysms, for which he is world-renowned. Prof Kalangos MD, PhD is a Greek-Swiss cardiovascular surgeon and Philanthropist. He currently serves as the Chairman of the Department of Pediatric and Congenital Cardiovascular Surgery at Mitera Hospital in Athens and as a full Professor of Pediatric Cardiovascular Surgery at Koc University Hospital in Istanbul, Türkiye. He is the President and founder of the Kalangos Foundation, the President and founder of the Global Forum on Humanitarian Medicine in Cardiology and Cardiac Surgery and the President and co- founder of Global Heart Network. He was the former President of the World Society of Cardiovascular and Thoracic Surgeons in 2014-2015 and is currently the treasurer of the society. He is also the inventor of the Kalangos biodegradable annuloplasty Rin. This device is being used in the repair of the mitral and tricuspid valves especially in children.

VOLUME I

PART I. Extracorporeal Life Support

Editorial Kaan Kirali

Introduction: Surgical Perspective Marko Turina

Introduction: Perfusional Perspective Gerard J. Myers

PART II. Artificial Circulation and Respiration

1. Development of Extracorporeal Circulation Steven Tsui and Ismail Vokshi

2. Future Artificial Surface Physiology Manoj Myneni and Keshava Rajagopal

3. Future Artificial Heart O.H. Frazier

4. Future Artificial Lung Justyna Swol

5. Future Noninvasive Monitoring Silvia Mariani, Maria De Piero and Axel Haveric

6. 3D Printing for Artificial Physiology Zhonghua Sun

7. Advances for Artificial Circulation Guidelines Kaan Kirali

PART III. Cardiopulmonary Bypass (CPB)

8. Basics of Extracorporeal Circulation

Vipin Zamvar and Peter Lang

9. Pathophysiology of Cardiopulmonary Bypass

Kaan Kirali, Davut Çekmecelioglu, Tanil Özer, Tolga Bas and Hülya Yük

10. Microcirculation During Cardiopulmonary Bypass

Thanos Athanasiou, Maria Fergadi and Dimitrios Magouliotis

11. Standards for Cardiopulmonary Bypass

David Fitzgerald and Justin Resley

12. Mechanical Pumps for Cardiopulmonary Bypass

Georg Maximilian Wieselthaler

13. Oxygenators for Cardiopulmonary Bypass

Korneel Vandewiele and Stefaan Bouchez

14. Cannulations for Cardiopulmonary Bypass

Gino Gerosa, Assunta Fabozzo and Chiara Tessari

15. Anesthesia During Cardiopulmonary Bypass

Antonio Pisano, Carolina Soledad Romero García, Nicola Galdieri and Giovanni Landoni

16. Monitoring During Cardiopulmonary Bypass

Kaan Kirali, Mustafa EMRE Gürcü, Pinar Karaca Baysal and Özlem Oguzhan

17. Transesophageal Echocardiography During Cardiopulmonary Bypass

Federico Pappalardo, Giulia Maj and Stephanie Bertolin

18. Hemostasis During Cardiopulmonary Bypass

Giuseppe G. Faggian, Francesco Onorati, Ilaria Tropea, Annalisa Bernabei and Alessandra Francica

19. Myocardial Preservation During Cardiopulmonary Bypass

Kaan Kirali, Hakan Hançer, Taylan Adademir, Tolga Bas and Mine Simsek

20. Cerebral Preservation During DHCA in Cardiopulmonary Bypass

Shahzad G. Raja

PART IV. Special Cardiopulmonary Bypass

21. Cardiopulmonary Bypass in Pregnancy

Hartzell Schaff and Sri Harsha Patlolla

22. Cardiopulmonary Bypass in Neonates and Infants

Akif Undar, Ryan M. Holcomb, Krishna Patel and Yongwook Dan

23. Cardiopulmonary Bypass in Pediatrics

Afksendiyos Kalangos and Nataliia Shatelen

24. Cardiopulmonary Bypass in Thoracic Aortic Surgery

Davut Çekmecelioglu, Kathleen Kibler, Vicente Orozco-Sevilla, and Joseph S. Coselli

25. Cardiopulmonary Bypass in Lung Transplantation

Alexander Sasha Krupnick, Aakash Shah and Joshua L. Leibowitz

26. Cardiopulmonary Bypass in Non-Cardiac Thoracic Surgery

Basar Sareyyüpoglu, Magdy M. El-Sayed Ahmed and Mathew Thomas

PART V. Special Situations for Perfusion

27. Perfusion Ethics, Accreditation and Education

David Fitzgerald and David Fisher Jr

28. Perfusion Training

Sven Maier and Christoph Benk

29. Perfusion Management

Filip De Somer

30. Perfusion Accidents Management

Carrel Thierry, Erich Gygax and Sarah Longnus-Henning

31. Perfusion Separation Challenge

Vladimir Lomivorotov and Ludmila Lomivorotova

32. Perfusion for HIPEC

Mustafa Duman, Erdal Polat, Mehmet Can, Kaan Kirali and Ercan Ersoy

Part VI. Miniaturizing Cardiopulmonary Bypass

33. Miniaturizing Cardiopulmonary Bypass (MiCPB)

Kyriakos Anastasiadis, Polychronis Antonitsis, Kyriakos Anastasiadis, Helena Argiriadou and Apostolos Deliopoulos

34. MiCPB in Cardiac Surgery

Konstantinos S. Mylonas and Dimitrios V. Avgerinos

35. MiCPB in Heart Valve Surgery

Kaan Kirali

36. MiCPB in Robotic Cardiac Surgery

Michael J. Bates, W. Douglas Boyd, L. Wiley Nifong and Randolph Chitwood

37. MiCPB in Pediatrics

Giovanni Battista Luciani, Alessio Rungatscher, Daniele Linardi and Stiljan Hoxha

Part VII. Organ Injury and Protection in Cardiopulmonary Bypass

38. Metabolic Aspects in Cardiopulmonary Bypass

John R. Cooper Jr, Katherine Gordon and Claudia Yu Yao Wei

39. Inflammatory Injury in Cardiopulmonary Bypass

Shahzad G. Raja

40. Inflammatory Protection and Immune Support for Cardiopulmonary Bypass

Shahzad G. Raja

41. Lung Injury in Cardiopulmonary Bypass

Stephen C. Clark and Vikrant Pathania

42. Pulmonary Protection and Respiratory Support for Cardiopulmonary Bypass

Kaan Kirali, Halide Ogus, Mustafa Mert Özgür and Ugur Eke

43. Brain Injury in Cardiopulmonary Bypass

Michael P. Vallely, Fabio Ramponi, Kaye Hon, Michael Seco, John D. Puskas, Jonathon Fanning, Stuart Grieve, Paul Bannon and Leonard Kritharides

44. Cerebral Protection and Neurologic Support

John M. Murkin and Agya Boakye Atonsah Prempeh

45. Kidney Injury in Cardiopulmonary Bypass

Eduard Quintana, Cristina Ibáñez, Juan Perdomo, Alícia Molina-Andujar and Esteban Poch

46. Renal Protection and Nephritic Support for Cardiopulmonary Bypass

Kaan Kirali, Özge Altas, Mustafa Emre Gürcü and Sefika Kiliç

47. Splanchnic Protection and Support for Cardiopulmonary Bypass

Paulo Roberto Barbosa Evora, Gabriel Bianco Giuliani, Cecilio Jacob and Patricia Martinez

48. Intestinal Protection and Enteric Support for Cardiopulmonary Bypass

Amer Harky, Kelly Wright and Naomi Melamed

49. Endocrinological Protection and Hormonal Support for Cardiopulmonary Bypass

Paulo Roberto Barbosa Evora, Gabriel Bianco Giuliani, Cecilio Jacob and Patricia Martinez

50. Vessels Injury in Cardiopulmonary Bypass

Assunta Fabozzo, Chiara Tessari, Giorgia Cibin and Gino Gerosa

51. Infectional Protection and Antimicrobial Support for Cardiopulmonary Bypass

Kaan Kirali, Yesim Uygun Kizmaz, Pinar Atagün Güney and Nuray Çankaya