3D Lung Models for Regenerating Lung Tissue

Professor in lung biology with a specific focus on extracellular matrix linked to structural changes and lung function in human chronic lung diseases. During the past decade, her research focus has shifted more towards developing human 3D lung model systems and bioreactors. She was the Dean of the Medical Department at Lund University for 6 years, and one of the chairs of the national board of SciLifeLab, working with infrastructure in Life Science at a national level to facilitate the use and edge of different techniques. Dr. Enes is an associated researcher in lung biology with a specific focus on stem cells and their interactions with the microenvironment. During the recent years, her research focus has been on how the microenvironment affects the biology and function of stem cells and how this knowledge could be applied to improve cell therapy. In 2019, she was involved in putting together and leading a session on the topic “From 2D to 3D models of human lung disease: novel developments to rebuild the lung” for the large European Respiratory Society (ERS) annual congress. In addition, she was invited to write a landmark paper on bioartificial lungs.

Part I: Standard 2D culture on plastic 1. 2D culture on plastic, past, present, important findings and breakthroughs 2. The importance of microenvironment (ECM, GAG)

Part II: 3D lung models 3. ALI model 4. Biofilms 5. Lung organoid models 6. 3D models Artificial material 7. 3D extracellular matrix models 8. Lung-on-a-chip 9. Flow, Mechanical properties, and bioreactors   10. Challenges with 3D models and Future directions  

Part III: New directions 11. 3D printing and bioprinting 12. Drug-screening and high throughput in 3D lung models 13. Model validation 14. AI and computational modelling 15. Conclusions