Cardiac Toxicology

Volume I.


1. Biochemical and Ionic Mechanisms of Cardiotoxic Agents.  2. Myocardial Function and Drug Actions.  3. Effects of Cardiotoxic Agents on the Electrical Properties of Myocardial Cells.  4. Pathomechanism of Chemically Induced Cardiac Arrhythmias.  5. Pathophysiology of the Heart in Shock.  6. The Role of Coronary No-Flow, Reflow Phenomenon to Myocardial Injury.  7. Reversible and Irreversible Injury: Calcium as a Major Determinant.  8. The Heart as a Target Organ in Immune Hypersensitivity Reactions.


Volume II.


1. Cardiac Toxicology of Inhalation Anaesthetics.  2. Cardiac Toxicology of Ethanol.  3. Clinical Toxicology of Digitalis.  4. Experimental Subchronic Digoxin Toxicosis in the Dog.  5. Unwanted cardiac Effects of Antihypertensive Drugs.  6. Cardiotoxicity of Adrenergic Bronchodilator and Vasodilating Antihypertensive Drugs.  7. Studies on the Cardiotoxicity of α- and β-Adrenergic Amines.  8. Cardiotoxicity of β-Adrenergic Blocking Agents.  9. The Cardiotoxicity of Neuroleptic and Tricyclic Antidepressant Drugs.  10. Myocardial Toxicity of Antibiotics.  11. Cardiotoxicity of Antineoplastic Drugs.  12. Studies in Food Additive Cardiomyopathies.  13. The Effects of Industrial Chemicals on the Heart.  14. Comparative Cardiotoxicity of Fluorocarbons.


Volume III.


1. An Overview of the Safety Evaluation of Chemicals with Respect to Cardiac Toxicology.  2. Assessment of Cardiotoxic Effects in Subacute and Chronic Rat Toxicity Studies.  3. The Use of Electrocardiography in Toxicological Studies with Beagle Dogs.  4. Overview of the Morphologic Reactions of the Heart to Toxic Injury.  5. Morphological Evaluation of the Heart in Toxicology Studies.  6. In Vitro Assessment of Cardiotoxicity.  7. Development Cardiotoxic Effects of Chemicals.  8. Cardiovascular Complications and Treatments of Drug Overdose.