Biochemistry of Drug Metabolizing Enzymes

Dr. Akash is currently working as associate professor and chairman at Department of Pharmaceutical Chemistry, Government College University Faisalabad (GCUF), Pakistan. He got his bachelor and master’s degrees in pharmacy from Bahauddin Zakariya University Multan, Pakistan and PhD degree in Pharmaceutical Analysis from Zhejiang University, China. Currently, he is focusing on investigating the effect of EDCs on various molecular and metabolic pathways that are involved in metabolic disorders and the treatment strategies of these EDCs-induced metabolic disorders funded by Higher Education Commission (HEC) of Pakistan. His Research work is the cutting edge and worthy of extension in developing countries like Pakistan, where it can be most beneficial and cost-effective especially for diabetic patients. Based on his significant scientific contributions in the field of Pharmaceutical Sciences, he has been awarded “Research Productivity Award” from Pakistan Council for Science and Technology (PCST), PAS Gold Medal from Pakistan Academy of Sciences and A.R. Shakoori Gold Medal from Zoological Society of Pakistan. Dr. Kanwal Rehman PhD is working as Associate Professor at Department of Pharmacy in The Women University, Multan, Pakistan. Dr. Kanwal Rehman received her PhD in Pharmacology and Toxicology from Zhejiang University, Hangzhou, China in 2015. She nurtures a keen interest in pathogenesis of metabolic disorders like diabetes mellitus, obesity, and new therapeutic modalities for its treatment. Other work includes detection of environmental pollutants and their cytotoxic effects. She has published about 135 articles. She has also published 50 book chapters with international publishers and 4 books with Springer-Nature. Currently, she is focusing on the investigation of role of pharmacogenomics based upon gene polymorphism on various molecular and metabolic pathways that are involved in mitogenic disorders and treatment strategies like natural biogenic compounds against different risk factors of metabolic disorders including pancreatitis, cardiometabolic disorders and hormonal imbalance. Dr. Kanwal Rehman has also been awarded Research productivity award by Pakistan Council for Science and Technology (PCST), Pakistan.

1. Biochemical activation of drug metabolizing enzymes: From mechanism of action to functions 2. Computational approaches and drug metabolizing enzymes: Concepts and challenges 3. Biotransformation of drugs by drug metabolizing enzymes: Concepts and challenges 4. Emerging environmental contaminants and drug metabolizing enzymes: Retrospective analysis and prospects 5. Impact of prodrugs on drug metabolizing enzymes: From function to regulation 6. Impact of hormones on drug metabolizing enzymes: From function to regulation 7. Impact of receptors on drug metabolizing enzymes: From function to regulation 8. Biochemistry of cathepsin enzymes and metabolic functions in lysosome 9. Fate of drug metabolizing enzymes in metabolic diseases: Challenges and strategies 10. Fate of drug metabolizing enzymes in cardiovascular diseases: Challenges and strategies 11. Fate of drug metabolizing enzymes in neurological diseases: Challenges and strategies 12. Impact of physiological factors on drug metabolizing enzymes: Challenges and strategies 13. Xenobiotics and drug metabolizing enzymes: Challenges and strategies 14. Drug metabolizing enzymes and inflammatory responses: Mechanism of induction and treatment strategies 15. Polymorphism and drug metabolizing enzymes: Challenges and strategies 16. Modulation of human microbiome and drug metabolism: Current trends and future prospects 17. Bioanalytical techniques for prediction of metabolic activity of drug metabolizing enzymes: Challenges 18. Role of pharmacogenomics for prediction of personalized medicines: Concepts and challenges 19. Dietary sources of drug metabolizing enzymes: From production to regulation 20. Vitamin deficiencies and drug metabolizing enzymes: Challenges and strategies 21. Malnutrition and Drug metabolizing enzymes: Challenges and strategies 22. Drug metabolizing enzymes and oxidative stress: Mechanism of induction and treatment strategies