Cardiac Electrophysiology

Jose Jalife, MD, is Professor of Internal Medicine and Cyrus and Jane Farrehi Professor of Cardiovascular Research; Professor of Molecular and Integrative Physiology; and Director of the Center for Arrhythmia Research at the University of Michigan in Ann Arbor

PART I: STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION Chapter 1. Sodium Channels - Eduardo Marban Chapter 2. Cardiac Calcium Channels - Donald M. Bers Chapter 3. Voltage Regulated Potassium Channels - Gavin Y. Oudit, Rafael J. Ramirez and Peter H. Backx Chapter 4: Intracellular Signaling and Regulation of Cardiac Ion Channels - Anant Khositseth, David E. Clapham, and Michael J. Ackerman Chapter 5: Membrane Pumps and Exchangers - Larry V. Hryshko Chapter 6: Sarcoplasmic Reticulum Ion Channels - Gerhard Meissner. Chapter 7: HCN Channels: From Genes to Function - Andreas Ludwig, Juliane Stieber, Sven Moosmang, Stefan Herrmann, Martin Biel, Franz Hofmann Chapter 8: Molecular Organization and Regulation of the Cardiac Gap Junction Channel Connexin43 - Mario Delmar , Heather S. Duffy, Paul Sorgen, Steven M. Taffet, David C. Spray PART II: BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION Chapter 9: Biophysics of Normal and Abnormal Cardiac Sodium Channel Function - Jeffrey R. Balser Chapter 10: Gating of Cardiac Delayed Rectifier K+ Channels - Michael C. Sanguinetti and Martin Tristani-Firouzi Chapter 11: Heart Mechanoelectric Transduction - Frederick Sachs Chapter 12: Pacemaker Channels and Normal Automaticity - Dario DiFrancesco Chapter 13: Biophysical Properties of Inward Rectifier Potassium Channels - Justus Anumonwo Chapter 14: Homomeric and Heteromeric Gap Junctions - Volodya Hayrapetyan, Guoqiang Zhong, Agustin D. Martinez and Eric C. Beyer. Alonso P. Moreno PART III: INTERMOLECULAR INTERACTIONS AND PHARMACOLOGY OF CARDIAC ION CHANNELS Chapter 15: Pharmacology of the Cardiac Na Channel - Jonathan C. Makielski, Bin Ye, Timothy J. Kamp, and Craig T. January Chapter 16: Pharmacology of L-type and T-type channels in the heart - Xiongwen Chen and Steven R. Houser Chapter 17: KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease - Sheila Carrol, Junko Kurokawa, and R.S. Kass Chapter 18: Drug-induced Channelopathies - Charlie Antzelevitch Chapter 19: Prospects for Pharmacological Targeting of Gap Junction Channels - Miduturu Srinivas, Heather Duffy, Mario Delmar, David C. Spray PART IV: ION CHANNELS AND CELLULAR ELECTROPHYSIOLOGY Chapter 20: Heterogeneous expression of Potassium channels - Jeanne M. Nerbonne Chapter 21: Gap Junction Distribution and Regulation in the Heart - Jeffrey E. Saffitz, Deborah L. Lerner, Kathryn A. Yamada Chapter 22: Cellular Mechanisms of Sinoatrial Activity - Itsuo Kodama, Haruo Honjo, Halina Dobrzynski, Mark R. Boyett Chapter 23: Mechanisms of AV nodal Excitability and Propagation - Igor R. Efimov and Vladimir P. Nikolsk Chapter 24: Intercellular Communication and Impulse Propagation - Andre G. Kleber Chapter 25: Cardiac tissue architecture Determines speed and safety of propagation - Stephan Rohr and Jan P. Kucera Chapter 26: Restitution, Repolarization and Alternans as Arrhythmogenic Substrate - Kenneth R. Laurita, Ph.D. and David S. Rosenbaum, M.D. Chapter 27: Mechanoelectric Transduction/Feedback: Prevalence and Pathophysiology - Max J. Lab PART V: MODELS OF CARDIAC EXCITATION Chapter 28: Ionic mechanisms of cardiac electrical activity: A Theoretical Approach - Yoram Rudy Chapter 29: Two-dimensional propagation in cardiac muscle - Bradley Roth Chapter 30: Three-dimensional Propagation in Mathematical Models - Craig S. Henriquez, Joseph V. Tranquello, David Weinstein, Edward Hsu, Christopher R. Johnson Chapter 31: Modeling Cardiac Defibrillation - Natalia Trayanova PART VI: NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY Chapter 32: Molecular and cellular bases of beta- and -adrenergic modulation of cardiac rhythm - Susan F. Steinberg, Richard B. Robinson, Michael R. Rosen Chapter 33: Nerve Sprouting and Cardiac Arrhythmias. - Lan S. Chen, Peng-Sheng Chen Chapter 34: Cholinergic Atrial Fibrillation - Leonid V. Rosenshtraukh, Vadim V. Fedorov, Oleg F. Sharifov PART VII: NONLINEAR DYNAMICS, SPIRALS AND HEART RHYTHMS Chapter 35: Theory of reentry - Marcel Wellner and Omer Berenfeld Chapter 36: Nonlinear Dynamics of Excitation and Propagation in Cardiac Muscle - Zhilin Qu, Alan Garfinkel Chapter 37: Rotors and Spiral Waves in Two Dimensions - Leslie Tung, Nenad Bursac, Felipe Aguel Chapter 38: Scroll waves in three dimensions - Arkady M. Pertsov PART VIII: ARRHYTHMIA MECHANISMS Chapter 39: Electrophysiology of the Pulmonary Veins: Mechanisms of initiation of atrial fibrillation - Jeffrey E. Olgin Chapter 40: Mechanisms of Maintenance of Atrial Fibrillation - Omer Berenfeld Chapter 41: Electrical Remodeling and Chronic Atrial Fibrillation - David R. VanWagoner Chapter 42: Mechanisms of Initiation of Ventricular Tachyarrhythmias - Jiashin Wu, Jianyi Wu, and Douglas P. Zipes Chapter 43: Dynamics and Molecular Mechanisms of Ventricular Fibrillation in Normal Hearts - Jose Jalife Chapter 44: Mechanisms of ventricular fibrillation in the ischemic heart - Alexey Zaitsev Chapter 45: Cellular mechanisms of defibrillation - Vladimir G. Fast Chapter 46: Global mechanisms of defibrillation - Richard A.Gray Chapter 47: Defibrillation Waveforms - Raymond E. Ideker, Joan Huang, Gregory Walcott PART IX: MOLECULAR GENETICS AND PHARMACOGENOMICS Chapter 48: Mouse Models of Cardiac Arrhythmias - Barry London Chapter 49: Human molecular Genetics and the Heart - Jeffrey A. Towbin, Neil Bowles Chapter 50: Genetics of Long QT, Brugada and other channelopathies. - Silvia G. Priori, Ilaria Rivolta, Carlo Napolitano Chapter 51: Pharmacogenomics of Cardiac Arrhythmias and Impact on Drug Therapy - Dan M. Roden PART X: CLINICAL ARRHYTHMIAS MECHANISMS, FEATURES AND MANAGEMENT SUPRAVENTRICULAR ARRHYTHMIAS Chapter 52: Sinus rhythm abnormalities - David J. Callans and David J. Lin Chapter 53: Atrioventricular Block And Atrioventricular Dissociation - David Schwartzman Chapter 54: Atrial Flutter: Mechanisms, Clinical Features and Management - Albert L. Waldo Chapter 55: Atrial tachycardia - Kenneth A. Ellenbogen and Mark A. Wood Chapter 56: Atrial fibrillation - Stanley Nattel and Joachim R. Ehrlich Chapter 57: Junctional Rhythms and Tachycardia - Hakan Oral and S. Adam Strickberger Chapter 58: Atrioventricular reentry and variants - Bradley P. Knight and Fred Morady Chapter 59: Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Reentrant Circuits - Deborah Lockwood, Kenichiro Otomo, Zulu Wang, Sara Forresti, Hiroshi Nakagawa, Karen Beckman, Benjamin J Scherlag, Eugene Patterson, Ralph Lazzara, and Warren M. Jackman Chapter 60: Atrial arrhythmias in congenital heart disease - John K. Triedman VENTRICULAR TACHYCARDIAS Chapter 61: Ventricular tachycardia in patients with coronary artery disease - David J. Callans, Mark E. Josephson Chapter 62: Ventricular Tachycardia in Patients with Dilated Cardiomyopathy - Joseph M. Galvin and Jeremy N. Ruskin Chapter 63: Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy - Guy Fontaine, Paul Fornes, Jean-Louis Hebert, Catherine Prost-Squarcioni, Xavier Jouven, Jean-Sebastian Hulot, Robert Frank, Daniel Thomas Chapter 64: Ventricular tachycardia in hypertrophic cardiomyopathy - Barry J. Maron Chapter 65: Ventricular Tachycardia In Patients With Hypertrophy And Heart Failure - Marc A. Vos, Harry J. Crijns, MD Chapter 66: Ventricular tachycardia in patients following surgery for congenital heart disease - George F. Van Hare Chapter 67: Brugada Syndrome - Josep Brugada, Pedro Brugada, Ramon Brugada, Charles Antzelvitch, Jeffrey Towbin Chapter 68: Catecholaminergic Polymorphic ventricular tachycardia and short-coupled Torsades de Pointes - Carlo Napolitano and Silvia G. Priori Chapter 69: Arrhythmias in Patients with Neurological Disorders - William J. Groh Chapter 70: Long QT syndrome - Phenotype-Genotype Considerations - Peter J Schwartz and Silvia G Priori Chapter 71: Long QT Syndrome - Therapeutic Considerations - Arthur J. Moss, Wojciech Zareba Chapter 72: Ventricular tachycardia in patients with structurally normal hearts - Bruce B. Lerman, Kenneth M. Stein, Steven M. Markowitz, Suneet Mittal, Sei Iwai Chapter 73: Bundle branch reentry - Emile Daoud Chapter 74: Torsades De Pointes - Nabil El-Sherif and Gioia Turitto Chapter 75: Accelerated Idioventricular Rhythm, Bi-directional Ventricular Tachycardia - Wolfram Grimm and Francis E. Marchlinski Chapter 76: Ventricular fibrillation - Andrew Epstein Chapter 77: Prolonged Repolarization And Sudden Infant Death Syndrome - Peter J. Schwartz and Marco Stramba - Badiale Chapter 78: Sudden cardiac death - Robert J. Myerburg, Alberto Interian Jr., Jeffery Simmons, Agustin Castellanos PART XI: ELECTROCARDIOGRAPHIC RECOGNITION Chapter 79: Exit block, supernormal conduction, concealed conduction - Michael J. Kilborn and Mark A. McGuire Chapter 80: Parasystole - Augustin Castellanos, Nadir Saoudi, Federico Moleiro, Robert J. Myerburg Chapter 81: Differential Diagnoisis of Wide QRS Complex Tachycardia - John M. Miller, Mithilesh K. Das, Rishi Arora, Cesar Alberte-Lista, Jianyi Wu PART XII: DIAGNOSTIC EVALUATION Chapter 82: Assessment of the patient with a cardiac arrhythmia - Douglas P. Zipes and William M. Miles Chapter 83: Exercise-induced cardiac arrhythmias - Ruey Sung, Chi Tai Kuo, Wen Ter Lai Chapter 84: Use of Long?Term (Holter) Electrocardiographic Recordings - Harold L. Kennedy Chapter 85: Use of implantable loop recordings - Andrew Krahn, George J. Klein, Allan C. Skaines, Raymond Yee Chapter 86: High-resolution electrocardiography - Edward J. Berbari Chapter 87: Body surface potential mapping - Bruno Taccardi, Bonnie B. Punske, Nora Eceles Harrison Chapter 88: Head-up tilt table testing - David G. Benditt, Cengiz Ermis, Fei Lu Chapter 89: Heart Rate Variability and Baroreflex Sensitivity - Marek Malik Chapter 90: Monophasic action potential recording - Michael R. Franz Chapter 91: T wave alternans - Stefan H. Hohnloser Chapter 92: Neurocardiac imaging - Gary D. Hutchins, Michael A. Miller and Douglas P. Zipes Chapter 93: Mapping - Vias Markides, Oliver R. Segal, Fernando Tondato, Nicholas Peters PART XIII: CLINICAL SYNDROMES: RECOGNITION, CLINICAL COURSE, AND MANAGEMENT Chapter 94: Wolff-Parkinson-White Syndrome - Eric Prystowsky, Raymond Yee, George J. Klein Chapter 95: Sinus Node Dysfunction - Michael Sweeney Chapter 96: Syncope - Hugh Calkins Chapter 97: Results of clinical trials on atrial fibrillation -D. George Wyse Chapter 98: Results of clinical trials of AEDs and ICDs in Patients at Risk for Sudden Death on ventricular arrhythmias with AEDs and ICDs - Alfred Buxton PART XIV: THERAPY PHARMACOLOGICAL Chapter 99: Class I antiarrhythmic drugs: quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide, propafenone - Anne Gillis Chapter 100: Beta-blockers and calcium channel blockers - Bramah Singh Chapter 101: Class III Antiarrhythmiac Drugs: Amiodarone, Ibutilide and Sotalol - Timothy W. Smith, Michael E. Cain Chapter 102: Adenosine and digoxin - John DiMarco Chapter 103: Impact of non-traditional antiarrhythmic drugs on sudden cardiac death - Jeffrey Goldberger, Kenneth Weinberg, Alan Kadish Chapter 104: New antiarrhythmic drugs - N A Mark Estes III ELECTRICAL Chapter 105: Transthoracic cardioversion and defibrillation - Richard E. Kerber Chapter 106: Implantable cardioverter defibrillators: Technical aspects - Bruce L. Wilkoff Chapter 107: Implantable cardioverter defibrillators: Clinical aspects - Charles Swerdlow and Kalyanam Shiukumar Chapter 108: Implantable atrial defibrillator for atrial fibrillation - Sam Levy Chapter 109: Implantable Pacemakers - David L. Hayes Chapter 110: Newer Applications of Pacemakers - Michael R Gold, MD, PhD and Robert W Peters MD Chapter 111: Biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation - David E. Haines Chapter 112: Focal catheter ablation for atrial fibrillation - Michel Haissaguerre, Prashanthan Sanders, Pierre Jais, Meleze Hocini, Dipen C. Shah, Jacques Clementy Chapter 113: Pulmonary vein isolation for atrial fibrillation - Carlo Pappone and Salvatore Rosanio Chapter 114: Catheter ablation of atrial flutter - Hans Kottkamp and Gerhara Hindricks Chapter 115: Catheter Ablation of Atrial Tachycardia - Chin-Feng Tsai, Ching-tai Tai, Shih-Ann Chen Chapter 116: Catheter Ablation of Atrioventricular Nodal Reentrant Tachycardia - Jonathan M. Kalman Chapter 117: Catheter Ablation of Atrioventricular Reentry - Sabie Ernst, Feifan Ouyang, Matthias Antz, Ricardo Cappato, Karl Heinz Kuck Chapter 118: Catheter ablation of ventricular tachycardia - William Stevenson and Kyoko Soejima Chapter 119: Catheter ablation in pediatric patients - John D. Kugler Chapter 120: Surgery for cardiac arrhythmias - Pierre L. Page