Hematology

Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY Chapter 1Anatomy and Physiology of the Gene Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner Chapter 2Genomic Approaches to the Study of Hematologic Science Todd Golub and Scott Armstrong Chapter 3Protein Synthesis, Processing, and Degradation Garabet G. Toby and David L. Wiest Chapter 4Protein Architecture: Relationship of Form and Function Alan C. Rigby and Barbara C. Furie Chapter 5Regulation of Cellular Response Benjamin G. Neel and Christopher Carpenter Chapter 6Cell Adhesion Rodger P. McEver Chapter 7Control of Cell Division William M.F. Lee and Chi V. Dang Chapter 8Cell Death David M. Hockenbery and Stanley J. Korsmeyer Chapter 9Pharmacogenomics and Hematological Diseases Loe Kager and William E. Evans Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY Chapter 10Overview and Compartmentalization of the Immune System Leland D. Powell and Linda G. Baum Chapter 11B-Cell Development Kenneth Dorshkind and David J. Rawlings Chapter 12T-Cell and NK-Cell Immunity Carol Clayberger and Alan M. Krensky Chapter 13Dendritic Cell Biology Zbigniew M. Szczepiorkowski and Nina Bhardwhaj Chapter 14Regulation of Activation of B and I Lymphocytes John C. Monroe and Lawrence Turka Chapter 15Leukocyte Trafficking James J. Campbell, Steven Sloan, and Leslie E. Silberstein Chapter 16Tolerance and Autoimmunity Mark J. Shlomchik Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS Chapter 17Stem Cell Model of Hematopoiesis Anskar YH Leung and Catherine M. Verafaillie Chapter 18Bone Marrow Microenvironment Mo Dao and Catherine M. Verfaillie Chapter 19The Humeral Regulation of Hematopoiesis Montaser Shaheen and Hal Broxmeyer Chapter 20Biology of Erythropoiesis, Erythroid Differentiation, and Maturation Thalia Papayannopoulou, Alan D'Andrea, Janis Abkowitz, and Anna Rita Migliaccio Chapter 21Granulopoiesis and Monocytopoiesis Arati Khanna-Gupta and Nancy Berliner Chapter 22Thrombocytopoiesis Michael W. Long and Ronald Hoffman Chapter 23Thrombocytopenia Due to Decreased Platelet Production J. B. Opalinska and Alan M. Gewirtz Chapter 24Inherited Forms of Bone Marrow Failure Melvin H. Freedman Chapter 25Aplastic Anemia Neal S. Young and Jaroslaw P. Maciejewski Chapter 26Paroxysmal Nocturnal Hemoglobinuria Rob A. Brodsky Chapter 27Pure Red Cell Aplasia Emmanuel N. Dessypris Part IV. RED BLOOD CELLS Chapter 28Pathobiology of the Human Erythrocyte and Its Hemoglobins Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert Chapter 29Approach to Anemia in the Adult and Child Peter Marks and Bertil Glader Chapter 30Anemia of Chronic Diseases Lawrence B. Gardner and Edward J. Benz, Jr. Chapter 31Pathology of Iron Metabolism Nancy C. Andrews Chapter 32Disorders of Iron Metabolism: Iron Deficiency and Overload Gary M. Brittenham Chapter 33Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias James S. Wiley and Michael R. Moore Chapter 34Megablastic Anemias Aook C. Anthony Chapter 35Thalassemia Syndromes Bernard G. Forget and Alan R. Cohen Chapter 36Pathology of Sickle Cell Disease Robert P. Hebbel Chapter 37Sickle Cell Disease Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah Chapter 38Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias Edward J. Benz, Jr. Chapter 39Red Cell Enzymopathies Xylina T. Gregg and Josef T. Prchal Chapter 40Red Cell Membrane Disorders Patrick G. Gallagher and Petr Jarolim Chapter 41Autoimmune Hemolytic Anemias Melody J. Cunningham and Leslie E. Silberstein Chapter 42Extrinsic Nonimmune Hemolytic Anemias Stanley L. Schrier and Erin Gourley Reid Part V. HOST DEFENSE AND ITS DISORDERS Chapter 43Complement Biology and Immunoglobulin Gregory Kline, Robert Barrington, and Michael C. Carroll Chapter 44Normal Phagocyte Structure and Function Robert L. Baehner Chapter 45Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes Steven J. Ackerman and Joseph H. Butterfield Chapter 46Disorders of Phagocyte Function and Number Mary C. Dinauer and Thomas D. Coates Chapter 47Disorders of Lymphocyte Function Aileen M. Cleary, Richard A. Insel, and David B. Lewis Chapter 48Histiocytic Disorders Jeffrey M. Lipton and Robert J. Arceci Chapter 49Lysosomal Storage Diseases: Perspective and Principles Gregory A. Grabowski and Nancy Leslie Chapter 50Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop Chapter 51The Spleen and Its Disorders Susan B. Shurin Chapter 52Basophils, Mast Cells, and Systemic Mastocytosis Robert I. Parker and Dean D. Metcalfe Part VI. HEMATOLOGIC MALIGNANCIES Chapter 53Conventional Cytogenetics and Molecular Cytogenetics in Hematological Malignancies Gordon Dewald and Rhett P. Ketterling Chapter 54The Molecular Basis of Neoplasia Carol Westbrook Chapter 55Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis Chapter 56Radiation Therapy in the Treatment of Hematologic Malignancies Andrea K. Ng and Peter M. Mauch Chapter 57Clinical Use of Hematopoietic Growth Factors Jacob M. Rowe and Irit Avivi Chapter 58Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma Thomas E. Witzig Chapter 59Pathobiology of Acute Myeloid Leukemia Brian Huntly and D. Gary Gilliland Chapter 60Clinical Manifestations of Acute Myeloid Leukemia Kenneth B. Miller and Philip R. Daoust Chapter 61Therapy for Acute Myeloid Leukemia Elihu H. Estey and Hagop Kantarijan Chapter 62Acute Myeloid Leukemia in Children Gary V. Dahl and Howard J. Weinstein Chapter 63Pathobiology of Acute Lymphoblastic Leukemia A. Thomas Look and Adolpho Ferrando Chapter 64Clinical Manifestations of Acute Lymphoblastic Leukemia Stacey L. Berg, C. Philip Steuber, and David G. Poplack Chapter 65Treatment of Childhood Acute Lymphoblastic Leukemia Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen Chapter 66Acute Lymphoblastic Leukemia in Adults Dieter Hoelzer and Nicola Gokbudget Chapter 67Myelodysplastic Syndrome: Biology and Treatment Richard Stone and Daniel DeAngelo Chapter 68Polycythemia Vera Ronald Hoffman, Kelty R. Baker and Joe Prchal Chapter 69Chronic Myeloid Leukemia Charles Sawyers and Neil P. Shah Chapter 70Myelofibrosis with Myeloid Metaplasia Ronald Hoffman and Farhad Ravandi-Kashani Chapter 71Essential Thrombocythemia Steven Fruchtman and Ronald Hoffman Chapter 72Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz Chapter 73Pathobiology of Non-Hodgkin Lymphomas Gianluca Gaidano and Riccardo Dalla-Favera Chapter 74Patho-Biology of Hodgkin's Lymphoma Stefano A. Pileri, Brunangelo Falini and Harold Stein Chapter 75Hodgkin's Disease: Clinical Manifestations, Staging, and Therapy Volker Diehl, Daniel Re, and Andreas Josting Chapter 76The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas Elaine Jaffe and Stefania Piltaluga Chapter 77Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce Chapter 78Malignant Lymphomas in Childhood John T. Sandlund, Jr.Michael P. Link Chapter 79Chronic Lymphocytic Leukemia Dilip V. Patel and Kanti R. Rai Chapter 80Hairy Cell Leukemia Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman Chapter 81Cutaneous T-Cell Lymphomas Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen Chapter 82AIDS-Related Lymphomas David T. Scadden Chapter 83Multiple Myeloma and Other Plasma Cell Disorders Guido Tricot Chapter 84Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL) Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien Chapter 85Atypical Immune Lymphoproliferations Timothy C. Greiner and Thomas G. Gross Chapter 86Clinical Approaches to Infections in the Compromised Host Jo-Anne H. van Burik Chapter 87Nutritional Support of Patients with Hematologic Malignancies Polly Lenssen and Saundra N. Aker Chapter 88Psychosocial Aspects of Hematologic Disorders Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta Chapter 89Pain Management and Antiemetic Therapy in Hematologic Disorders Janet L. Abrahm, Lauren Dias, and Bridget Fowler Chapter 90Palliative Care Janet L. Abrahm and Barbara Sourkes Chapter 91Indwelling Access Devices Janet L. Abrahm and Linda M. Pellerin Chapter 92Late Complications of Hematologic Diseases and Their Therapies Wendy Landier and Smita Bhatia Part VII. TRANSPLANTATION Chapter 93Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases andMyelodysplastic Syndrome William Tse and H. Joachim Deeg Chapter 94Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases Stella M. Davies Chapter 95Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies Andrea Bacigalupo Chapter 96Autologous Transplant for Hematologic malignancies and Solio Tumors Stephen J. Forman and Jeffery R. Schriber Chapter 97Unrelated Donor Stem Cell Transplantation Therapy Effie W. Petersdorf and Claudio Anasetti Chapter 98Umbilical Cord Blood Transplantation Juliet N. Barker and John E. Wagner Chapter 99Preparative Regimens for Hematopoietic Cell Transplantation Marcos de Lima and Sergio Giralt Chapter 100Graft-versus-Host Disease and Graft-versus-Leukemia Pavan Reddy and James L.M. Ferrara Chapter 101Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease andProvide a Graft-versus-Tumor Effect Catherine M. Bollard and Adrian P. Gee Chapter 102Gene Transfer for Hematologic Disorders Katherine A. High and Malcolm K. Brenner Chapter 103Experimental Cell Therapy Robert S. Negrin Chapter 104Complications After Hematopoietic Cell Transplantation Daniel J. Weisdorf Part VIII. HEMOSTASIS AND THROMBOSIS Chapter 105Megakaryocyte and Platelet Structure Joseph E. Italiano and John Hartwig Chapter 106The Molecular Basis for Platelet Function Edward F. Plow and Charles S. Abrams Chapter 107The Molecular Basis for Platelet Activation Lawrence F. Brass Chapter 108The Blood Vessel Wall Aly Karsan and John M. Harlan Chapter 109Molecular Basis of Blood Coagulation Bruce Furie and Barbara C. Furie Chapter 110Molecular and Cellular Basis of Fibrinolysis H. Roger Lijnen and Desire Collen Chapter 111Regulatory Mechanisms in Hemostasis: Natural Anticoagulants Charles T. Esmon Chapter 112Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura Barry S. Coller and Paul I. Schniederman Chapter 113Laboratory Evaluation of Hemostatic Disorders Jacob H. Rand and Lisa Senzel Chapter 114Structure, Biology, and Genetics of Factor VIII Randal J. Kaufman and Stylianos E. Antonarakis Chapter 115Biochemistry of Factor IX and Molecular Biology of Hemophilia B S. Jamie Freedman and Bruce Furie Chapter 116Clinical Aspects and Therapy of Hemophilia Jay Nelson Lozier and Craig M. Kessler Chapter 117Inhibitors in Hemophilia Donald I. Feinstein Chapter 118Other Clotting Factor Deficiencies Harold R. Roberts and Miguel A. Escobar Chapter 119Disorders of Fibrinogen Jose Martinez and Andres Ferber Chapter 120Structure, Biology, and Genetics of von Willebrand Factor David Ginsburg and Denisa D. Wagner Chapter 121von Willebrand Disease: Clinical Aspects and Therapy Gilbert C. White, II, and J. Evan Sadler Chapter 122Vitamin K: Metabolism and Disorders Barbara C. Furie and Bruce Furie Chapter 123Inhibitors of Blood Coagulation Donald I. Feinstein Chapter 124Disseminated Intrvascular Coagulation Howard A. Liebman and Ilene C. Weitz Chapter 125Hemostatic Defects Associated with Dysproteinemias Howard A. Liebman Chapter 126Disorders of Coagulation in the Neonate Leonardo R. Brandao and Donna DiMichele Chapter 127Hypercoagulable States Kenneth A. Bauer Chapter 128Venous Thromboembolism Mark A. Crowther and Jeffrey S. Ginsberg Chapter 129Arterial Thromboembolism Mark A. Crowther and Jeffrey S. Ginsberg Chapter 130Anticoagulation and Thrombolytic Therapy Jeffrey I. Weitz Chapter 131Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura James Bussel and Douglas Cines Chapter 132Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome Keith R. McCrae, J Evan Sadler, and Douglas Cines Chapter 133Thrombocytopenia Due to Platelet Destruction and Hypersplenism Theodore E. Warkentin and John G. Kelton Chapter 134Hereditary Disorders of Platelet Function Joel S. Bennett Chapter 135Acquired Disorders of Platelet Function Jose Lopez and Perumal Thiagarajan Part IX. TRANSFUSION MEDICINE Chapter 136Human Blood Group Anitgens and Antibodies Part 1: Carbohydrate Determinants Part 2: Protein Determinants Marion E. Reid and Martin L. Olsson Chapter 137Human Platelet Antigens Thomas J. Kunicki and Diane J. Nugent Chapter 138Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek Chapter 139Principles of Red Blood Cell Transfusion Paul M. Ness and Margot S. Kruskall Chapter 140Principles of Platelet Transfusion Therapy Thomas S. Kickler Chapter 141Principles of Neutrophil (Granulocyte) Transfusions Ronald G. Strauss Chapter 142Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins Cassandra D. Josephson and Christopher D. Hillyer Chapter 143Preparation of Plasma-Derived and Recombinant Human Plasma Proteins William N. Drohan and David B. Clark Chapter 144Transfusion Therapy for Coagulation factor Deficiencies Catherine S. Manno and Peter Larson Chapter 145Hemapheresis and Cellular Therapy Ellen F. Lazarus and Harvey G. Klein Chapter 146Practical Aspects of Stem Cell Collection Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu Chapter 147Transfusion Reactions Edward L. Snyder and YanYun Wu Chapter 148Transfusion-Transmitted Diseases Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove Chapter 149Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik Chapter 150Red Blood Cell Substitutes Robert M. Winslow Part X. CONSULTATIVE HEMATOLOGY Chapter 151Hematologic Manifestations of Systemic Disease: Liver and Renal Disease Rachel Rosovsky and Peter W. Marks Chapter 152Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, andCancer Peter W. Marks and David S. Rosenthal Chapter 153Hematologic Manifestations of AIDS David H. Henry and James A. Hoxie Chapter 154Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis Mark T. Reding and Nigel S. Key Chapter 155Hematologic Aspects of Pregnancy Edward J. Benz, Jr. Chapter 156Hematologic Manifestations of Childhood Illness A. Kim Ritchey and Frank G. Keller Part XI. SPECIAL TESTS AND PROCEDURES Chapter 157Bone Marrow Examination Daniel H. Ryan and Harvey J. Cohen Chapter 158Automated Analysis of Blood Cells Raymond E. Felgar and Daniel H. Ryan Chapter 159Laboratory Detection of Hemoglobinopathies and Thalassemias Martin H. Steinberg and David Chui Chapter 160Antenatal Diagnosis of Hematologic Disorders Kim Kramer and Harvey J. Cohen Chapter 161Use of Molecular Techniques in the Analysis of Hematologic Diseases Michele Paessler and Adam Bagg Chapter 162Molecular Imaging in Hematology Francis G. Blankenberg AppendixNormal Blood Values: Selected Reference Values for Neonatal, Pediatric, and AdultPopulations Sharon M. Geaghan