Cholesterol Metabolism in Aging and Disease

Mark Mc Auley, PhD, is senior lecturer in chemical engineering at the University of Chester. He completed his PhD entitled “Systems Modelling of Human Ageing” under the tutelage of Professor Tom Kirkwood, CBE, an internationally acclaimed ageing researcher and Professor Darren Wilkinson an internationally renowned researcher in statistics. His teaching centers on applied biochemistry, biotechnology, molecular biology and bioinformatics. Mark has over 15 years’ experience of applying computing to challenges in bioscience. He uses computational modelling to help improve our understanding of complex biochemical pathways and research centers primarily on the ageing process. He has published over 30 peer-reviewed articles in the area of health, aging and nutrition.

1. Introduction
2. The role of Cholesterol in the Body
3. The Cholesterol Biosynthesis Pathway
4. Maintaining intracellular Cholesterol Homeostasis
5. The regulation of whole body Cholesterol Metabolism
6. How does aging impact Cholesterol Metabolism?
7. Cholesterol metabolism and Cardiovascular Disease
8. Cholesterol Metabolism and Cancer
9. Cholesterol Metabolism and Alzheimer’s Disease
10. Cholesterol Metabolism in the Oldest old
11. How Diet and Alcohol influences Cholesterol Metabolism
12. Computational Models of Cholesterol metabolism