The ADME Encyclopedia

Dr. Talevi holds a permanent position at the Argentinean National Council of Scientific and Technical Research since 2010 and is the professor in charge of the Biopharmacy/Pharmacokinetics course at the Faculty of Exact Sciences, University of La Plata. He has published over 70 articles in periodicals and more than 25 book chapters, mostly in the fields of rational drug discovery and biopharmacy. He served as the Head of the Department of Biological Sciences of the Faculty of Exact Sciences, University of La Plata and now serves as the the Head of the Laboratory of Bioactive Research and Development (LIDeB, University of La Plata). He has been an external reviewer for these several agencies and universities, including the Argentinean National Institute of Cancer, Argentinean National Agency of Scientific and Technical Promotion, Argentinean Ministry of National Education, the University of La Republica (Uruguay), University of Cordoba (Argentina), University of Buenos Aires (Argentina), University of San Luis (Argentina), the National Agency of Scientific and Technical Promotion (Uruguay) and the National Science Center (Poland). He has been a reviewer for over 80 periodicals and is a member of the Argentinean Society of Protozoology and the International Research Network on Dravet and Refractory Epilepsy (INDRE). Also he has taught several PhD courses and postgraduate courses in Argentina, Uruguay and Mexico, and acted as invited speaker/lecturer at several meetings and seminars in Argentina, Uruguay, Mexico, Brazil, Spain and Ireland. Recipient of several national and international research grants. PI of a bioinformatics node of a Marie Curie RISE (Research and Innovation Staff Exchange) H2020e in addition to supervising 4 approved PhD theses and currently supervising another 5 along with 4 approved degree theses.

• Drug dissolution and drug release
• Mathematical models of drug dissolution and drug release
• Diffusion layer model
• Danckwert's model
Interfacial barrier model
• First order model
• Higuchi model
• Korsmeyer-Peppas model
• Hixson-Crowell model
Baker-Lonsdale model
• Weibull model
• In vitro dissolution testing
• Modalities of dissolution tests
• Biorelevant dissolution media

• Drug absorption
• Free diffusion
• Facilitated diffusion
Active transport
• Transcytosis
• pH partition theory
• pKa determination
• Factors impacting drug absorption

• Drug distribution
• Factors impacting drug distribution
• Real volume of distribution
Apparent volume of distribution
• Drug binding to plasma proteins
• Drug displacement
• Non-linear binding to plasma proteins
• Drug binding to tissue components
• One-compartment pharmacokinetic model
• Two-compartment pharmacokinetic model
• Central nervous system bioavailability
• Blood-brain barrier
log BB
• Kpuu

• Drug metabolism
• Functionalization reactions
• Synthetic reactions
• Cytochrome P450
• Phase III reactions
• Factors impacting on drug metabolism
• Genetic variants. Polymorphism
• Age
• Gender
• Environmental factors: enzyme induction
• Precision medicine
• Pharmacogenomic DNA chips
• Microsomes

•  Drug excretion
• Biliary excretion
Enterohepatic recycling
• Enterohepatic recycling and antibiotics
• Renal excretion
• Glomerular filtration
• Tubular reabsorption
• Tubular secretion
• Clearance
• Organ clearance

Routes of administration
• Oral route
• Migrating motor complex
• Enteric coating tablets
Food-drug interactions
• Gastric emptying
• Gastroretentive drug delivery systems
• Multiparticulate drug delivery systems
Gut microbiota
• Lipinski rule of five
• Permeation enhancers
• Intestinal perfusion models
• Bucal and sublingual route
Rectal route
• Intravenous route
• Intravenous bolus
• Intravenous infusion
• Technological considerations for intravenous administration
• Intramuscular administration
• Subcutaneous administration
• Specialized parenteral routes
• Pulmonary administration
• Nasal administration
• Transdermal administration
• Permeation enhancers

• Next generation drug delivery systems
Nanocarriers
• Surface-to-volume ratio
• Surface chemistry
• Nanotoxicology
• Drug release from nanocarriers
• Passive targeting
• Smart systems / stimuli-responsive systems
• Active targeting
• Mononuclear phagocyte system
• Absorption and distribution of nanocarriers
• Elimination of nanocarriers
• PEGylationADME
• Viral vectors

• Pharmacogenomics
• Enzyme polymorphism
• Transporter polymorphism
• Pharmacogenomics and pediatrics

Bioavailability and bioequivalence
• Bioavailability
• Systemic bioavailability
• Generic drugs
• Post-approval changes
• Bioequivalence
• Absolute bioavailability
• Mass balance studies
• Bioequivalence studies
• Reference and test products
Biopharmaceutical Classification System
• Biowaivers
• BCS subclasses
• Dissolution testing
• Pharmacodynamic studies

• Biopharmaceutical drug products
• Absorption of protein drugs
• Distribution of protein drugs
• Elimination of protein drugs
• ADME properties of insulins
• ADME properties of heparins
• ADME properties of gene-based biopharmaceuticals

Drug-drug and food-drug interactions
• Plasma protein binding DDI
• Membrane transport DDI
• Metabolism DDI
• FDI based on induction of gastrointestinal changes

• In vitro and in silico ADME predictions
• Polarized cell lines
• Caco-2
MDCK
• Solubility
• Dissolution testing
• QSPR/QSAR
• Expert rules
Central Nervous System Multiparameter Optimization
• Dynamic transit models
• Sandwich-cultured hepatocytes
• Single-cell expression systems
• Membrane vesicles
• Molecular dynamics simulations

• Drug tansporters
• ABC transporters
MDR1
• MRPs
• BCRP
• Solute carriers
• Organic anion transporters
Organic cation transporters
• Peptide transporters

• Non-linear pharmacokinetics
Linear pharmacokinetics
• Positive deviations from linear behavior
• Negative deviations from linear behavior

• Time-dependent pharmacokinetics

• Pharmacometrics and physiologic models