The EGF Receptor Family -

The EGF Receptor Family

Biologic Mechanisms and Role in Cancer

Graham Carpenter (Herausgeber)

Buch | Hardcover
166 Seiten
2004
Academic Press Inc (Verlag)
978-0-12-160281-9 (ISBN)
103,50 inkl. MwSt
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Consists of a collection of articles, each covering an aspect of the ErbB/EGF field. This book features articles on growth factor ligands, neuregulins, and individual receptors. It concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer.
The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.

Introduction
EGF Receptor Ligands
Neuregulins: Functions, Forms, and Signaling Strategies
Epidermal Growth Factor Receptor: Mechanisms of Activation and Signaling
The Deaf and Dumb: The Biology of ErbB-2 and ErbB-3
ErbB-4: Mechanism of Action and Biology
Trafficking of the ErbB Receptors and Its Influence on Signaling
Erbbs in Mammary Development
The ErbB Receptors and their Role in Cancer Progression
Ligand-Independent Oncogenic Signaling by the Epidermal Growth Factor Receptor: V-ErbB as a Paradigm
ErbB-Targeted Therapeutic Approaches in Human Cancer
Mechanism of Action of erbB Tyrosine Kinase Inhibitors
Signaling by the Drosophila Epidermal Growth Factor Receptor Pathway during Development
The Epidermal Growth Factor System in Caenorhabaditis Elegans

Erscheint lt. Verlag 6.2.2004
Verlagsort San Diego
Sprache englisch
Maße 206 x 276 mm
Gewicht 750 g
Themenwelt Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
ISBN-10 0-12-160281-8 / 0121602818
ISBN-13 978-0-12-160281-9 / 9780121602819
Zustand Neuware
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