Choroidal Neovascularization

Dr. Jay Chhablani is a Vitreo-Retina Specialist at the University of Pittsburgh Eye Center. He completed a clinical vitreo-retina fellowship at Sankara Nethralaya, Chennai, India, and was an International Council of Ophthalmology (ICO) fellow at Jules Gonin Eye Hospital, Switzerland, in 2009. He was a Clinical Instructor at the Jacobs Retina Center at Shiley Eye Center, University of California, San Diego, USA (2010 to 2012) before joining the faculty at L V Prasad Eye Institute, Hyderabad, India (2012-19). His areas of interest are macular disorders and recent imaging techniques. He has published more than 300 articles in peer-reviewed journals with a focus on the field of the choroid. He is the editor of the books Choroidal Disorders and Central Serous Chorioretinopathy, and he is on the review boards of all the high- impact ophthalmology journals. He is also on the editorial board of several specialty journals, including the American Journal of Ophthalmology. He is a member of the American Academy of Ophthalmology’s Global ONE network committee. He has won several national and international awards and delivered the inaugural Ian Constable lecture at the Asia-Pacific Vitreo-Retina Society in 2016. He received the Inaugural Namperumalsamy Young Researcher Award in 2018, presented by the Vitreo-Retina Society of India.

Section I: History.- History of choroidal neovascularization (CNV) - initial understanding and development.- Section II: Basics.- Pathogenesis – various proposed mechanisms.- Histopathology – recent understanding in relationship with imaging.- Electron microscopy – update in choroidal changes.- Section III: Clinical classification.- Neovascular age-related macular degeneration (AMD) – clinical features, imaging, protocols and outcomes.- CNV secondary to pathologic myopia – clinical features, imaging and treatment outcomes.- Pachychoroid related CNV – recent updates, imaging and outcomes.- Inflammatory CNV – clinical features, imaging and treatment outcomes.- Dystrophy related CNV – clinical features, imaging and treatment outcomes.- CNV secondary to angioid streaks – clinical features, imaging and treatment protocols.- Idiopathic CNV – clinical features, imaging and treatment outcomes.- CNV associated with idiopathic juxtafoveal telangiectasia –clinical features, imaging and treatment outcomes.- CNV associated with other causes – laser induced, idiopathic intracranial hypertension, choroidal osteoma, trauma, choroidal coloboma, choroidal nevus, etc.- Peripapillary CNVM – overview of various causes, imaging features and treatment outcomes.- Pediatric CNVM – overview of various causes, imaging features and treatment outcomes.- Polypoidal choroidal vasculopathy (PCV) – clinical features, imaging and treatment outcomes.- Section IV: Treatment options.- Anti-VEGF current options – Ranibizumab, Bevacizumab, Aflibercept, Ziv-aflibercept, Conbercept.- Photodynamic therapy – current status in anti-VEGF era.- Surgical intervention – graft, retinal implant, the implantable miniature telescope, surgical removal of CNV, subretinal tissue plasminogen activator.- Section V: Clinical trials.- n-AMD trials – comprehensive overview of PDT and anti-VEGF trials in AMD.- Myopic CNV trials – comprehensive overview of PDT and anti-VEGF trials in AMD.- Non-AMD CNV trials – comprehensive overview of various trials in non-AMD related CNV causes.- PCV trials – comprehensive overview of PDT and anti-VEGF trials in PCV.- Section VI: Future directions.- Stem cells in AMD – current status and future expectations.- Newer molecules – newer targets in CNV and the upcoming research.- Radiotherapy – role of radiotherapy and clinical trials.- Other options – role of subthreshold laser, and other therapies in CNV.- Section VII: Rehabilitation.- Low vision aids.- Peripheral vision development – newer approach for macular diseases.- Monitoring techniques – advanced home monitoring techniques and initial experience.