Methylxanthines and Phosphodiesterase Inhibitors in the Treatment of Airways Disease

Xanthines and xanthine-like drugs for asthma. Current status of cyclic nucleotide phosphodiesterase isoenzymes. The human cycle nucleotide phosphodiesterases. Phosphodiesterase inhibitors and airways muscle. Cyclic AMP phosphodiesterase inhibition, theophylline, and pharmacological inhibition of neutrophil and eosinophil function. The anti-inflammatory actions of theophylline and selective phosphodiesterase inhibitors: relevance to the therapy of allergic airways disease. The anti-inflammatory actions of theophylline. Methylxanthines in the treatment of cystic fibrosis. Clinical efficacy o theophylline in chronic obstructive pulmonary disease. Future prospects for cyclic nucleotide phosphodiesterase isoenzyme inhibitors in asthma. Index.