Paul's Fundamental Immunology

MARTIN FLAJNIK, PhD Professor, University of Maryland Baltimore School of Medicine Dept. of Microbiology and Immunology Baltimore, MD USA 21201 Education Martin Flajnik graduated from the Pennsylvania State University in 1978 with a BS in Biology. He earned an MS in 1979 and a PhD in 1983 from the University of Rochester (NY) in Microbiology and Immunology. He was a postdoc (and completed his PhD) from 1983-1988 at the Basel Institute for Immunology under Louis Du Pasquier, and rose to professor in his first independent academic position at the University of Miami (FL) (1988-97). He has been a professor at the University of Maryland Baltimore School of Medicine since 1998. Honors and Awards "Faculty Member of the Year Award," teaching award sponsored by the Microbiology and Immunology University of Miami undergraduates, 1995 Plenary talks at the International Immunology Meetings of 1989 and 1995 Co-editor of the journal Immunogenetics since 2001 Vice President of the International Society of Developmental and Comparative Immunology (ISDCI) (2001-2007) GPILS teacher of the year, UMB Graduate School, 2008 "Immunological Guru” and plenary speaker at the NIH Immunology Retreat, 2010 Funded by the NIH continually from 1988-present Contributed a chapter to Fundamental Immunology editions 5-7 (1992-2012) and co-editor of the 8th edition (2022) Research Interests My work is centered on the evolution of the adaptive immune system, with the major goal being to understand the origins of adaptive immunity. I was involved in the early biochemical and molecular characterization of lower vertebrate MHC, and have identified several immunoglobulin and T cell receptor isotypes in ectothermic vertebrates. Our lab recently has become interested in the evolution of lymphoid tissues. NEVIL J. SINGH, PhD Assistant Professor University of Maryland Baltimore Baltimore, Maryland   STEVEN M. HOLLAND Director, Division of Intramural Research NIAID, National Institutes of Health Bethesda, Maryland  

Contents
 
Contributors vii
Foreword xiii
Preface xvii
 
Section I. Introduction to Immunology
1 Overview of the Immune System — 1
Martin F. Flajnik, Steven M. Holland, Nevil J. Singh
2 History of Immunology — 29
Edward J. Moticka
 
Section II. Evolution of the Immune System
3 The Insect Immune System — 52
Sara Cherry, Nicolas Buchon
4 Evolution of the Vertebrate and Lower Deuterostome Immune System — 79
Martin F. Flajnik
5 The Plant Immune System — 134
Roger W. Innes
 
Section III. Cellular Pathways and Processes in Immunity
6 Immunometabolism —  161
Jonathan D. Powell, Chirag H. Patel, Im- Hong Sun
7 Regulated Cell Death in the Immune System — 204
Douglas R. Green, Sebastian Ruehl
8 Lymphoid Tissues and Organs — 228
Martin F. Flajnik, Nancy H. Ruddle
9 Type I Cytokines, Interferons, and Their Receptors — 258
Achsah D. Keegan, Warren J. Leonard
10 Tumor Necrosis Factor Superfamily of Cytokines and Receptors — 308
Carl F. Ware, Nancy H. Ruddle
11 Chemokines and Chemokine Receptors — 344
Philip M. Murphy
 
Section IV. Innate Immunity
12 Pattern Recognition Receptors and the IL- 1 Family — 386
Rajendra Karki, Thirumala- Devi Kanneganti
13 The Complement System — 416
Erin E. West, Claudia Kemper
14 Neutrophils — 455
Andres Hidalgo, Mariana J. Kaplan
15 Macrophages — 469
Gwendalyn J. Randolph
16 Mast Cells and Basophils — 487
Mindy Tsai, Stephen J. Galli
17 Eosinophils — 519
Elizabeth A. Jacobsen, Hirohito Kita
18 The Biology of Natural Killer Cells and Innate Lymphoid Cells — 537
Vincent Peng, Marco Colonna
 
Section V. Adaptive Immunity
19 The Major Histocompatibility Complex — 573
David H. Margulies, Kannan Natarajan, Jamie Rossjohn, James McCluskey
20 Classical Antigen Processing and Presentation — 622
Jonathan W. Yewdell, Paul Roche, Laurence C. Eisenlohr
21 Immunoglobulins: Structure and Function — 644
Mohamed Khass, David Wald, Neil S. Greenspan, Harry W. Schroeder, Jr
22 Immunoglobulins: Molecular Genetics — 671
Sebastian D. Fugmann
23 T Cell Antigen Receptors and Antigen Recognition — 702
Mark M. Davis, Yueh- Hsiu Chien
24 Antigen Receptor Signaling — 734
Nevil J. Singh, Gideon Wolf
25 B Cell Development in Mice — 774
Nicole Baumgarth
26 B Cell Responses — 798
Claude- Agnès Reynaud, Jean- Claude Weill
27 T Cell Development in the Thymus — 823
Avinash Bhandoola, Remy Bosselut, Yousuke Takahama
28 CD4+ Helper T Cells: Differentiation, Flexibility, and Heterogeneity — 856
John J. O’Shea, Marion Pepper, Marc K. Jenkins, Danielle A. Chisolm
29 Regulatory T Cells — 874
Ethan M. Shevach
30 CD8+ T Cell Memory — 924
Francis R. Carbone, Thomas Gebhardt
31 Cytotoxic Effector Functions — 944
Morgan Huse
 
Section VI. Integrative Immunology
32 Immunologic Tolerance — 971
Colin C. Anderson, Troy A. Baldwin, Peter A. Bretscher
33 Fc Receptors and Their Role in Immune Regulation and Inflammation — 1008
Jeffrey V. Ravetch, Aaron Gupta, Falk Nimmerjahn
34 Dendritic cells — 1034
Roxane Tussiwand, Pierre Guermonprez, Simon Yona
35 Gamma Delta T Cells — 1054
Adrian C. Hayday
36 CD1- Restricted T Cells — 1102
Pankaj Sharma, Florian Winau
37 Mucosal- Associated Invariant T Cells and Other MR1- Reactive T Cells — 1137
Sidonia B. G. Eckle, Wael Awad, Jamie Rossjohn, James McCluskey, Alexandra J. Corbett
38 The Mucosal Immune System — 1178
Yasmine Belkaid, Brian L. Kelsall, Warren Strober
39 Introduction to Neuroimmunology — 1212
Andrea Francesca Salvador, Jonathan Kipnis
40 Vaccines — 1231
Bali Pulendran
41 Maternal- Fetal Immunology — 1283
Gabrielle Rizzuto, Adrian Erlebacher
 
Section VII. Immune Responses to Pathogens
42 Response to Parasites — 1325
David Sacks, Marion Pepper, Mary F. Fontana, P’ng Loke
43 Immune Responses to Bacteria — 1355
S. Celeste Morley, Moon H. Nahm
44 Response to Viruses — 1399
Hildegund C. J. Ertl
45 Immunology of HIV Infection — 1445
Gaurav D. Gaiha, Douglas S. Kwon
 
Section VIII. Immunological Disease States and Immunodeficiency
46 Autoimmunity and Autoimmune Diseases — 1465
Gustaf Christoffersson, Ken T. Coppieters, Matthias von Herrath, Dirk Homann
47 Immunologic Mechanisms of Allergic Disorders — 1515
Stéphanie Lejeune, Kari C. Nadeau, David W. Scott, Joshua D. Milner
48 Transplantation Immunology — 1549
Megan Sykes, Anita S. Chong, Markus Y. Mapara
49 Cancer Immunology and Immunotherapy — 1589
Thomas F. Gajewski, Justin Kline
50 Inborn Errors of Immunity — 1619
Isabelle Meyts, Jean- Laurent Casanova, Luigi D. Notarangelo
 
Index 1649