Metastatic Potential of Human Colorectal Cancer Cell Lines

This book presents a concise review of the current knowledge regarding the pathophysiology of human colorectal cancer, with particular emphasis on the mechanisms leading to matastasis. Topics addressed include the culture and properties of human colorectal cancer cell lines, growth and metastasis of human cancers in the nude mouse, mechanisms of invasion, interaction with cell at the metastasis target organ (with special consideration of the liver), and angiogenesis. The book also explores the potential of therapy directed specifically at metastasis and the use of experimental models in vivo and in vitro to study metastasis in human cancers.