Pharmaceutical Inhalation Aerosol Technology

Factors governing aerosol deposition and targeting in the lung: physiology of the airways, Anthony J. Hickey and David C. Thompson; pharmacology of therapeutic aerosols, David C. Thompson; targeting by deposition, Igor Gonda; drug targeting to the lung - chemical and biochemical considerations, Peter A. Crooks; lung deposition simulation, Warren Finlay; lung deposition imaging, Myrna Dolovich; pharmacokinetics and pharmacodynamics of drugs delivered to the lungs, G. Hochhaus; methods of generation, administration and characterization of aerosols - theoretical principles and devices used to generate aerosols for research, Keng H. Leong; the design and development of inhalation drug delivery systems, Paul J. Atkins, Nicholas P. Barker and Donald Mathisen; aerosol-filling equipment for the preparation of pressurized pack pharmaceutical formulations, Christophe Sirand, Jean-Pierre Varlet and Anthony J. Hickey; methods of aerosol particle size characterization, Anthony J. Hickey; summary of common approaches to pharmaceutical aerosol administration, Anthony J. Hickey. Clinical aspects of aerosol administration and future perspectives: therapeutic aerosols - an overview from a clinical perspective, F. Charles Hiller; aerosolized pentamidine for treatment and prophylaxis of pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome, Bruce montgomery; the application of aerosolized antimicrobial therapies in lung infections, Dennis Williams; gene delivery to the lung, Justin Hanesl; recent advances related to the systemic delivery of therapeutic molecules by inhalation, David Edwards; modulated drug therapy with inhalation aerosols - revisited, Ralph W. Niven; pulmonary delivery technology - advances of the last decade and potential for the new millennium, Andy Clark.