Biology and Treatment of Leukemia and Bone Marrow Neoplasms

lt;br>Guido Marcucci, MD, is Chair and Professor in the Department of Hematologic Malignancies Translational Science and Professor in the Department of Hematology and Hematopoietic Stem Cell Transplantation at City of Hope (COH) Comprehensive Cancer Center in California. He is also Director of the Gehr Family Center for Leukemia Research at COH. Dr. Marcucci has conducted basic, translational, and clinical research in myeloid malignancies. His research focus has been on discovery of basic mechanisms of leukemogenesis, novel therapeutic targets, epigenetic and genetic prognostic biomarkers, and new drug development for AML and MDS. He has chaired several phase I, II, and III clinical trials as both single- and multi-institution studies within the oncology cooperative group Alliance (formerly known as CALGB), for which he is currently Vice-Chair of the Leukemia Committee and Member of the Leukemia Correlative Science Committee. Dr. Marcucci has published over 300 papers in peer-reviewed journals and has been uninterruptedly funded by the National Cancer Institute since 2001.

Vinod Pullarkat, MD, MRCP, is Professor in the Department of Hematology and Hematopoietic Cell Transplantation at City of Hope National Medical Center in Los Angeles, California. Dr. Pullarkat's clinical expertise is in the treatment of acute leukemia and other bone marrow neoplasms, including the use of hematopoietic stem cell transplantation.  He received his medical degree from University of Calicut, India, and undertook fellowship training in Hematology/Oncology at the University of Southern California, following which he served as Faculty in the Department of Hematology and Hematopoietic Cell Transplantation at City of Hope Medical Center and at the University of Southern California. Dr. Pullarkat's research focuses especially on the biology of acute leukemia, including mechanisms of chemotherapy resistance, and the development of new therapies for acute leukemia. He has been Principal Investigator on various leukemia clinical trials and has published extensively in the fields of acute leukemia biology and therapy as well as hematopoietic stem cell transplantation.

Advances in diagnosis and risk stratification of leukemias and bone marrow neoplasms.- Genetics and diagnostic approach to lymphoblastic leukemia.- Acute promyelocytic leukemia: update on risk stratification and treatment.- Current and emerging therapies for AML.- Current management and new developments in treatment of ALL.- Contemporary therapy of CML.- MDS:  Pathogenesis and therapy.- Chronic lymphocytic leukemia: Biology and therapy.- Biology and current treatment of Myeloproliferative neoplasms.- Systemic Mastocytosis: Pathology and treatment.- Adoptive T-cell therapy and other novel immunotherapies for leukemia.