Mechanisms and Models in Rheumatoid Arthritis

Part 1 Cellular mechanisms in rheumatoid arthritis: histopathology of rheumatoid joint, T. Freemont; pannus, D. Hamerman; synovial cells, B. Henderson and J. Edwards; chrondrocytes, R. Poole; bone cells and bone remodelling in rheumatoid arthritis, M. Gowen; t lymphocyte/macrophage interactions, L. Klareskog; leukocyte adhesion and leukocyte traffic in rheumatoid arthritis, D. Haskard. Part 2 Humoral mechanisms in rheumatoid arthritis: inflammatory cytokines including the IL-8 supergene family, S. Kunkel; cytokine inhibitors, B. Thompson; growth factors, R. Wilder; lipid mediators, G. Higgs; oxidants/free radicals, B. Halliwell; neuropeptides, J. Levine; proteases and connective tissue breakdown, J. Reynolds. Part 3 Animal models of rheumatoid arthritis: role of animal models in the study of rheumatoid arthritis - a general review, D. Willoughby; immunogenetics of animal models of rheumatoid arthritis, P. Woolley; adjuvant arthritis - the first model?, M. Billingham; arthritis induced by bacteria and viruses, B. Cole; streptococcal cell wall arthritis, J. Schwab; collagen-induced arthritis, D. Trentham; antigen-induced arthritis in rodents, W. Van den Berg; antigen-induced arthritis in the rabbit, R. Pettipher and B. Henderson. Part 4 Animal models of rheumatoid arthritis: spontaneous arthritis models, S. Gay; cytokine-induced arthritis, I. Otterness; animal models and anti-rheumatic drug development, R. Griffiths.