Isocitrate Dehydrogenase Inhibitors in Cancer Chemotherapy

Prof. Dr Robert Musiol received a PhD in organic chemistry in 2005 and habilitation in pharmacy in 2013. For roughly twenty years he is connected with University of Silesia in Katowice, Poland, where he teaches medicinal chemistry, pharmacology and toxicology. His scientific interest is focused on drug design and particularly polypharmacological design of potential anticancer drugs. Recently he is involved in redesign of IDH1 inhibitors towards multi-kinase activity. He is a co-author of more than one hundred scientific papers and thirty patents. Being involved in teaching and popularizing science, he was supervisor of four doctorates and more than forty master’s degree students.

1. Isocitrate dehydrogenase and its place in cellular metabolism
2. Wild type and mutant IDH as drug target
3. Holy grail of combination therapy? Possibilities and limitations of mono- and poli-therapies based on IDH1/2 inhibitors
4. Two faced IDH. The good and bad in prognosis
5. Inhibitors of IDH1/2 in leukemias
6. Inhibitors of IDH1/2 in gliomas and other brain tumors
7. Potential importance of IDH in gastrointestinal cancers
8. Isocitrate dehydrogenases as target for theranostics
9. Resistance emerging and therapeutic strategies
10. Challenges and future perspectives