The Hereditary Basis of Childhood Cancer

lt;p>Dr. Malkin is Professor of Pediatrics and Medical Biophysics in the Faculty of Medicine, University of Toronto. He holds the CIBC Children's Foundation Chair in Child Health Research, is a Senior Staff Oncologist in the Division of Hematology/Oncology, Director of the Cancer Genetics program, and a Senior Scientist in the Genetics and Genome Biology Program at The Hospital for Sick Children in Toronto. Dr. Malkin is the Lead of the SickKids Precision Child Health initiative. He is co-Director of the SickKids Cancer Sequencing (KiCS) program which integrates and translates next generation sequencing into clinical care of children with cancer, and Director of the pan-Canadian multi-institutional PRecision Oncology For Young peopLE (PROFYLE) initiative which is establishing a pipeline to incorporate next generation sequencing into novel clinical trials ('precision oncology') for children and young adults with hard-to-treat cancers across Canada. Dr. Malkin's research program focuses on genetic and genomic mechanisms of childhood cancer susceptibility which he has explored particularly in the context of TP53 and Li-Fraumeni syndrome. Recently, his work has addressed the application of genomics to develop rational clinical surveillance and treatment guidelines for children and adults at genetic 'high risk' for cancer. He has published over 250 peer-reviewed articles and has received several awards recognizing his dedication to clinical care, advocacy, research, medical education and mentorship.

1: Li-Fraumeni Syndrome.- 2: Pediatric Central Nervous System Cancer Predisposition.- 3: Rhabdoid Tumors.- 4: Neurofibromatosis.- 5: Pheochromocytoma and Paraganglioma syndromes.- 6: Wilms tumor.- 7: Hereditary Overgrowth Syndromes.- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions.- 9: DICER1 Syndrome.- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes.- 11: Inherited Risk for Childhood Leukemia.- 12: Inherited pediatric cancer in low and intermediate resource countries.- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research.- 14: Genetic counseling and testing.- 15: Psychosocial aspects of childhood cancer genetics.- 16: Recognition of cancer predisposition syndromes.