Insomnia Disorder

Jaime M. Monti is Professor, Department of Pharmacology and Therapeutics, School of Medicine, Clinics Hospital, University of the Republic, Uruguay. He is a member of the International College of Neuropsychopharmacology, Sleep Research Society (USA), European Sleep Research Society, and the Argentinian Society of Sleep Medicine. S.R. Pandi-Perumal, M.Sc, is the President and Chief Executive Officer of Somnogen Canada Inc, a Canadian Corporation. He is a well-recognized sleep researcher both nationally and internationally, and has authored many publications. He has edited over 20 volumes related to sleep and biological rhythms research and he serves as Editor-in-Chief for Progress in Sleep Research. His general area of research interest includes sleep and biological rhythms.

1. Neurobiology of sleep and waking
2. Neurotransmitters and sleep
3. Regulation of sleep and wakefulness (two-process model of sleep and three-process model of alertness)
3. Chronobiotics and chronohypnotics
4. Normal sleep in children adolescents, adults, and older adults
5. Insomnia: Overview and classification
6. Insomnia characteristics in children, adolescents, adults, and older adults
7. Mechanism of action of presently available hypnotic drugs
8. Pharmacokinetics of presently available hypnotic drugs
9. Non-pharmacological treatment of an insomnia disorder
10. Benzodiazepine hypnotics
11. “Zeta drugs”: Zopiclone, Eszopiclone, Zolpidem, and Zaleplon
12. Melatonin and melatonin receptor agonists (Ramelteon, Tasimelteon)
13. Histamine H1 receptor antagonists (with special emphasis on low-dose Doxepin)
14. Orexin receptor antagonists (Suvorexant, Lemborexant)
15. Insomnia and CAM therapies: an evidence-based approach