In Vitro Neurotoxicology -

In Vitro Neurotoxicology

Principles and Challenges
Buch | Hardcover
331 Seiten
2003
Humana Press Inc. (Verlag)
978-1-58829-047-2 (ISBN)
106,99 inkl. MwSt
Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.

In Vitro Neurotoxicology.- Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment.- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics.- In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis.- Role of Apoptosis in Neurotoxicology.- Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants.- Cell-Type Specific Responses of the Nervous System to Lead.- Effects of Toxicants on Neural Differentiation.- Impairment of Synaptic Function by Exposure to Lead.- Aggregating Brain Cell Cultures for Neurotoxicological Studies.- Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors.- Establishing In Vitro Models to Study Endogenous Neurotoxicants.

Erscheint lt. Verlag 1.12.2003
Reihe/Serie Methods in Pharmacology and Toxicology
Zusatzinfo XV, 331 p.
Verlagsort Totowa, NJ
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
Studium Querschnittsbereiche Infektiologie / Immunologie
ISBN-10 1-58829-047-6 / 1588290476
ISBN-13 978-1-58829-047-2 / 9781588290472
Zustand Neuware
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