Diagnosis and Management of Cholangiocarcinoma

James H. Tabibian, MD, PhD, FACPPhysician Specialist, GI-InvasiveDirector of EndoscopyDepartment of MedicineOlive View-UCLA Medical CenterHealth Sciences Clinical Associate ProfessorDavid Geffen School of Medicine at UCLA Los Angeles, CA USA

Anatomy of the Biliary Tree: Normal, Anomalous, and Relationship to Cholangiocarcinoma.- Anatomic and Morphologic Classifications of Cholangiocarcinoma.- Intraductal tumors of the biliary tract: Precursor lesions and variants.- Pathologic Basis and Classification of Biliary Epithelial Neoplasms.- Clinical epidemiology of cholangiocarcinoma.- Biochemical indicators of Cholangiocarcinoma.- Imaging of Cholangiocarcinoma.- Pathological diagnosis of cholangiocarcinoma.- Challenges in diagnosing cholangiocarcinoma: pulling together biochemical, radiological, and cytopathological data.- PSC-Associated Cholangiocarcinoma: Diagnostic And Therapeutic Considerations.- Fluke-associated Cholangiocarcinoma: a regional epidemic.- Endoscopic Management of Cholangiocarcinoma.- The Role of Endoscopic Ultrasound in Cholangiocarcinoma.- Surgical approach to the treatment of cholangiocarcinoma.- Liver Transplantation for Cholangiocarcinoma.- Neoadjuvant and Adjuvant Therapy for Cholangiocarcinoma.- Palliative chemotherapy and radiotherapy for cholangiocarcinoma.- Interventional Radiology Therapies for Intrahepatic Cholangiocarcinoma.- Established and emerging biomarkers for prediction, early detection, and prognostication of cholangiocarcinoma.- Cholangiocarcinoma Surveillance in Primary Sclerosing Cholangitis and IgG4-related sclerosing cholangitis.- Novel targeted therapies in clinical use and on the horizon for cholangiocarcinoma.- In vitro and in vivo model systems of cholangiocarcinoma.- Organoid models of Cholangiocarcinoma.- The tumor environment: cholangiocarcinoma-associated fibroblasts and beyond.- Glycosylation in cholangiocarcinoma development and metastasis: diagnostic and therapeutic considerations.- The investigative therapeutic pipeline for cholangiocarcinoma: insights from model systems