Human Genome Epidemiology

PART I: FUNDAMENTALS; 1. Human Genome Epidemiology: Scope and Strategies; 2. Emerging Genomic Technologies and Analytic Methods for Population- and Clinic-Based Research; 3. Approaches to Quantify the Genetic Component of and Identify Genes for Complex Traits; 4. Ethical, Legal and Social Issues in the Design and Conduct of Human Genome Epidemiology Studies; PART II: METHODS AND APPROACHES I: ASSESSING DISEASE ASSOCIATIONS AND INTERACTIONS; 5. Assessing Genotypes in Human Genome Epidemiology Studies; 6. Statistical Issues in the Design and Analysis of Gene-Disease Association Studies; 7. Facing the Challenge of Complex Genotypes and Gene-Environment Interaction: The Basic Epidemiologic Units in Case-Control and Case-Only Designs; 8. Inference Issues in Cohort and Case-Control Studies of Genetic Effects and Gene-Environment Interactions; 9. Applications of Human Genome Epidemiology to Environmental Health; 10. Reporting and Review of Human Genome Epidemiology Studies; PART III: METHODS AND APPROACHES II: ASSESSING GENETIC TESTS FOR DISEASE PREVENTION; 11. Epidemiologic Approach to Genetic Tests: Population-Based Data for Preventive Medicine; 12. Genetic Tests in Populations: An Evidence Based Approach; 13. ACCE: A Model Process for Evaluating Data on Emerging Genetic Tests; 14. The Interface Between Epidemiology and Pharmacogenetics; 15. Integrating Genetics Into Randomized Controlled Trials; 16. Developing Guidelines for the Clinical Use of Genetic Tests: A US Perspective; 17. Using Human Genome Epidemiologic Evidence in Developing Genetics Services: The UK Experience; PART IV: CASE STUDIES: USING HUMAN GENOME EPIDEMIOLOGY INFORMATION TO IMPROVE HEALTH; 18. Paraoxonase Polymorphisms and Susceptibility to Organophosphate Pesticides; 19. Factor V Leiden, Oral Contraceptives, and Deep Vein Thrombosis; 20. Methylenetetrahydrofolate Reductase Gene (MTHFR), Folate, and Colorectal Neoplasia; 21. Apolipoprotein E and Alzheimer Disease; 22. Immunogenetic Factors in Chronic Beryllium Disease; 23. Fragile X Syndrome: From Gene Identification to Clinical Diagnosis and Population Screening; 24. The Connexin Connection: From Epidemiology to Criminal Practice; 25. Genetic and Environmental Factors in Cardiovascular Disease; 26. BRCA1/2 and the Prevention of Breast Cancer; 27. The Role of Chemokine and Chemokine Receptor Genes in HIV-1 Infection; 28. Hereditary Hemochromatosis; 29. Genetic Testing of Railroad Track Workers with Carpal Tunnel Syndrome