Monoclonal Antibodies

Dr. Harleen Kaur research focuses on the development and characterization of large molecules, particularly monoclonal antibodies (mAbs) and bringing therapeutic molecules from early discovery and research stage to commercialization. Dr Kaur has previously worked for AstraZeneca and WuXi Biologics in the United States and has extensive experience in the development and testing of biologics as therapeutic molecules in a highly regulated environment. She earned her undergraduate degree from Guru Gobind Singh Indraprastha University, India, and PhD degree from the National University of Singapore, Singapore. Dr Kaur is the author of many peer-reviewed publications and book chapters in the area of antibody characterization and aptamers. She is also the lead editor of the book titled “Monoclonal Antibodies: Physicochemical Analysis” that was published by Elsevier. Dietmar Reusch, PhD, is affiliated with Roche Diagnostics GmbH in Germany. His research focuses on the analytical development and characterization of large molecules, particularly mAbs, and on bringing therapeutic products from entry into human to commercial launch.

1. Overview of Monoclonal Antibodies
2. Physicochemical Characterisation of Monoclonal Antibodies
3. Glycosylation Analysis
4. The Use and Application of LC-MS-MS Petide Mapping Methodology for Primary Structure Confirmation, Sequence Variant Analysis and Comprehensive Analysis of Post-Translational Modifications
5. Separation Techniques for Characterization and Quantification of Antibody Purity
6. Higher Order Structure and Free Thiol
7. Advanced Structural Elucidation of New Antibody Formats by Mass Spectrometry