The Heterogeneity of Cancer Metabolism

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Dr. Anne Le studied at the Paris Descartes University, Cochin Port-Royal School of Medicine, in France where she obtained a Habilitation degree, the highest academic qualification a scholar can achieve in Europe. After her clinical training at Henri Poincaré University Hospital, Nancy, in France, she started her postdoctoral research fellowship at the Johns Hopkins University School of Medicine in 2007. Since 2011, Dr. Le has been an independent investigator who has yielded a number of contributions to the field of cancer metabolism, demonstrated by her publication record as a pioneer in the field. She has published work in highly regarded journals, including Cell Metabolism and the Proceedings of the National Academy of Sciences of the United States of America. Dr. Le has been invited to present her work at several annual American Association for Cancer Research meetings, the most prestigious international meeting for cancer research scientists and professionals, as well as by the National Cancer Institute, and universities in France, Monaco, Japan, and Taiwan. Research media, such as Science Daily, American Association for the Advancement of Science (AAAS), Business Insider, ALN® Magazine, among many others, have written about her work. Dr. Le is regularly invited to serve on review panels by prestigious organizations such as the National Institutes of Health and the US Department of Defense.

Part I. Basic Metabolism of Cancer Cells.- Glucose Metabolism in Cancer the Warburg effect and Beyond.- Glutamine Metabolism in Cancer.- The Heterogeneity of Lipid Metabolism in Cancer.- Part II. Heterogeneity of Cancer Metabolism.- The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions.- The Intricate Metabolism of Pancreatic Cancers.- The heterogeneity of breast cancer metabolism for therapy.- Non-Hodgkin Lymphoma Metabolism.- The Heterogeneity Metabolism of Renal Cell Carcinomas .- The Heterogeneity Metabolism of Liver Cancer.- Different Tumor Microenvironments Lead to Different Metabolic Phenotypes.- The Intratumoral Heterogeneity of Cancer Metabolism.- Cancer Stem Cells Metabolism.- Metabolism of Immune cells in the Tumor Microenvironment.- Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts.- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells.- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts.- Part IV. The metabolic interplay between cancer and other diseases.- Diabetes and Cancer: the Epidemiological and Metabolic Associations.- Bridging the Metabolic Parallels between Neurological Diseases and Cancer.- Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy.- Index.