Oxidative Stress in Lung Diseases

Prof. Sajal Chakraborti is a Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases, oxidant and Ca2+ signalling in the pathogenesis of a variety of diseases. Prof. Chakraborti did is PhD from Calcutta University (1982) and DSc from Kalyani University (2014). He did his post- doctoral research at Johns Hopkins University, University of Utah and New York Medical College. He received DBT-Senior overseas research award for his research at the Brain Institute, University of Florida, Gainesville (1998-1999). He has been engaged in teaching and research in biochemistry for the past 40 years. He has published more than hundred original papers, 22 book chapters, 15 review articles and edited seven books published by Springer. Dr. Tapati Chakraborti is a Professor of Biochemistry at the University of Kalyani, West Bengal, India. Her research focuses on the determination of the Mechanisms Associated with the Role of Proteases in the Oxidant-mediated Cellular Dysregulation of Pulmonary Vascular Endothelial and Smooth Muscle Cells. She received Ph.D. from the CSIR-Indian Institute of Chemical Biology (affiliated to Jadavpur University, Kolkata in the year 1992 and did post-doctoral research at the Brain Institute, University of Florida, Gainesville, Florida during 1999-2002.  Dr. Tapati Chakraborti has been actively involved in teaching and research for the past 30 years. She has published more than 80 original research papers, 18 book chapters, and 12 review articles. She also edited a book entitled “Proteases in human diseases” published by Springer in the year 2017. Prof. Rita Ghosh is a Professor of Biophysics in the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. She did her MSc in Physics from Calcutta University and PhD from Saha Institute of Nuclear Physics, Kolkata. She did her post doctoral research at the Swiss Institute of Experimental Cancer Research, Lausanne, Switzerland (1991-1993). Her research covers mainly in the area of  cell biology..   She has been engaged in teaching and research for more than 30 years. She has published above 40 original research papers, review articles and books chapters.  Prof. Nirmal K. Ganguly was the Director General of Indian Council of Medical Research (ICMR), New Delhi and the Director of PGIMER (Chandigarh) and National Institute of Biologicals (Noida). Dr. Ganguly is currently a Distinguished Professor, Global Health Strategies at New Delhi, India and the Chief Advisor of the Policy Centre for Biomedical Research, Translational Health Science & Technology Institute, Faridabad, India and at Ganga Ram Institute for Postgraduate Medical Education & Research (GRIPMER). Dr. Ganguly has published over 780 research papers and has mentored 130 doctoral students leading to the fulfillment of Ph.D. dissertations as the Doctoral Advisor/Joint Advisor.  Currently, Dr. Ganguly also focuses on the Immunological Basis of Cancer as a major area of his research.  Dr. Ganguly is a Fellow of the Imperial College Faculty of Medicine, London, the Royal College of Pathologists, London,the International Academy of Cardiovascular Sciences, Canada, the Third World Academy of Sciences, Italy, and the International Medical Sciences Academy, New Delhi. Dr. Ganguly is also a Fellow of all the National Academies of Sciences. He has received more than 119 awards, including 8 International and 111 National Awards. He has been honored with the prestigious Indian National Padma Bhushan Award presented to him by the President of India, on 26th January, 2008 in the field of Medicine. Dr. Narasimham L Parinandi is currently an Associate Professor in Department of Internal Medicine and Division of Pharmacology, The Ohio State University, Columbus, Ohio. Dr. Parinandi earned his Ph.D. (1986) at the University of Toledo, Toledo, OH, USA.  He did his post doctoral research (1986-90) at the Hormel Institute, University of Minnesota, where he was associated with Prof. Harald Schmid (a celebrity in the area of lipid biochemistry) and  Prof. Ralph T. Holman (Member of the National Academy of Sciences, USA). He was a research scientist at the Johns Hopkins University School of Medicine (1998-2002). Dr. Parinandi also collaborated with Dr. Louis J. Ignarro, a recipient of the 1998 Nobel Prize in Physiology (for signaling properties of nitric oxide). He has published 120 original research papers, reviews, and book chapters, and edited a book on Free Radicals and Antioxidant Protocols with Prof. William Pryor, the legendary Free Radical and Lipid Peroxidation Scientist. Dr. Parinandi is an Associate Editor of Cell Biophysics & Biochemistry (Springer). Dr. Parinandi has teaching and mentoring experience of more than 37 years in the US universities and has mentored over 75 students in his laboratory at 4 major US universities.

A.  General Aspects of reactive oxygen species-mediated lung diseases



1.  “Pathology of lung diseases affected by oxidative stress”



 2. “Approach of smoke-related lung damage” 



 3. “The state of art of NADPH Oxidase-dependent oxidative stress in lung diseases” 



 4. “Effects of radicals on pulmonary surfactant and role of lipid in this scenario”



 5. “Infection induced oxidation and DNA repair”



 6. “Oxidative stress in experimental models of acute lung injury” 
 7. “Oxidative Lipidomics of Lung Diseases”



 



 B.  Chronic lung diseases



 8. “Oxidative stress in Lung Fibrosis”



9. “Oxidative Stress Biomarkers in COPD”



10. “Oxidative stress in emphysema”



11. “Oxidative stress induced mitochondrial dysfunction and asthma”



12. “Oxidative stress in asthma and COPD” 



 



 D. Other lung diseases



13. “Oxidative stress in environmental lung diseases”



 14. “Bronchopulmonary dysplasia and oxidative stress in preterm newborns”



 15. “Effect of exogeneous chemical exposure on oxidative stress induced lung diseases”



 16. “Pulmonary antioxidant system in acute and chronic lung injury, pulmonary fibrosis in diabetes”



 17.“Mitochondrial alterations and oxidative stress in cystic fibrosis”



 



 E. Prevention and therapeutics



18. “Flagellin/Toll-like receptor 5 response was specifically attenuated by keratin sulfate disaccharide via decreased EGFR phosphorylation in human bronchial epithelial cells”/



19. “Therapeutic targeting of oxidative stress and inflammation in COPD and asthma: Pharmacological intervention with phytochemicals”



20. “ROS: modulator of therapeutic response in non-small cell lung cancer (NSCLC)”



21. “Arsenic-induced lung injury in rats and its reversal by a garlic polysulfide” 



22. “The Mitochondria-targeted Drugs for Protection of Lung Damage and Pulmonary Diseases”.



23. “The use of ozone as redox modulator in the treatment of chronic pulmonary disease (COPD)”



24. “Oxidative stress and therapeutic development in lung cancer”



25.The state of art of NADPH Oxidase-dependent oxidative stress in lung diseases.



26.   Pharmacological modulation of  ROS impairs the airway hyper responsiveness by shifting the Th1 response in allergic inflammation induced by ovalbumin



27.   Flagellin/Toll-like receptor 5 response was specifically attenuated by keratin sulfate disaccharide via decreased EGFR phosphorylation in human bronchial epithelial cells.



28.  Oxidative stress in experimental models of acute lung injury.



 29. Pharmacokinetics, pharmacodynamics and safety of ISO1957, a preclinical candidate possessing activity against infection.



30. Rho kinase as a therapeutic target in pulmonary vascular diseases.



31. Mesenchymal stromal cell injection protects against oxidative stress in E.coli induced lung injury in mice.



32.  Phosgene induced lung damage and its amelioration by cAMP elevating compounds.