Mammary Tumorigenesis and Malignant Progression

I. Proliferation, Differentiation, and Malignant Progression.- 1. Morphological and biological observations relating to the development and progression of breast cancer.- 2. Growth, differentiation, and transformation of human mammary epithelial cells in culture.- II. Genetic Basis for Cancer Onset and Progression.- 3. Genetic analysis of breast and ovarian cancer in families.- 4. The p53 tumor-suppressor gene in human breast cancer.- 5. Tumor-suppressor genes in breast cancer progression.- 6. Estrogen receptor variants in breast cancer.- 7. Hormone ‘resistance’ in breast cancer: the role of normal and mutant steroid receptors.- III. Growth Factors, Receptors, and Polyamines.- 8. The epidermal growth factor family in the mammary gland and other target organs for ovarian steroids.- 9. Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase.- 10. MDGF1: a multifunctional growth factor in human milk and human breast cancer.- 11. The role of polyamines in the hormonal control of breast cancer cell proliferation.- IV. Cancer Cell Adhesion, Migration, and Proteolysis.- 12. Modulations of the epithelial phenotype during embryogenesis and cancer progression.- 13. Cell-cell adhesion in invasion and metastasis of carcinomas.- 14. Enhancement of tumor growth by basement membrane: modulation of growth and angiogenesis by laminin-derived synthetic peptides.- 15. Fetal-like fibroblasts: their production of migration-stimulating factor and role in tumor progression.- 16. Urokinase plasminogen activator (uPA) and its type inhibitor (PAI-1): regulators of proteolysis during cancer invasion and prognostic parameters in breast cancer.- V. Rodent Model Systems of Breast Cancer.- 17. Molecular mechanisms of chemical carcinogenesis in rodent models.- 18. Fgf-3, anoncogene in murine breast cancer.