Protein Allostery in Drug Discovery

Buch | Softcover

384 Seiten

2020 | 1st ed. 2019
Springer Verlag, Singapore
978-981-13-8721-0 (ISBN)

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The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA

Chapter 1. Allostery in Drug Development.- Chapter 2. Dynamic Protein Allosteric Regulation and Disease.- Chapter 3. Protein Allostery in Rational Drug Design.- Chapter 4. Progress in Allosteric Database.- Chapter 5. Correlation between Allosteric and Orthosteric Sites.- Chapter 6. Characteristics of Allosteric Proteins, Sites and Modulators.- Chapter 7. Advances in the Computational Identification of Allosteric Sites and Pathways in Proteins.- Chapter 8. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands.- Chapter 9. Interrogating Regulatory Mechanisms in Signal-ling Proteins by Allosteric Inhibitors and Activators: A Dynamic View through the Lens of Residue Interaction Network.- Chapter 10. GPCR Allosteric Modulator Discovery.- Chapter 11. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.- Chapter 12. Allosteric regulation of protein kinases downstream of PI3-kinase signaling. Chapter 13. Allosteric Modulators of Protein-Protein Interactions (PPIs).- Chapter 14. Allosteric Modulation of Intrinsically Disordered Proteins.- Chapter 15. Engineering Allostery into Proteins.

Erscheinungsdatum	16.01.2021
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1163
Zusatzinfo	82 Illustrations, color; 21 Illustrations, black and white; XII, 384 p. 103 illus., 82 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik ► Medizintechnik
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	Allosteric Drug Discovery • allosteric modulator • Allosteric regulation • Allosteric Site • Protein Allostery
ISBN-10	981-13-8721-4 / 9811387214
ISBN-13	978-981-13-8721-0 / 9789811387210
Zustand	Neuware