New Therapies in Advanced Cutaneous Malignancies

Piotr Rutkowski is Professor of Surgical Oncology at the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Poland. Dr Rutkowski is the current Head of the Department of Soft Tissue/Bone Sarcoma and Melanoma, the Plenipotentiary Director of Institute for Clinical Trials at the Maria Sklodowska-Curie Institute - Oncology Center as well as the VicePresident of Scientific Council of Maria Sklodowska-Curie Institute - Oncology Center. He has participated in several investigator-driven trials in melanoma and sarcoma. He is also Coordinator of the Polish Clinical GIST Registry, and a reviewer for several international scientific journals, as well as a member of the Editorial Board of Annals of Surgical Oncology and European Journal of Surgical Oncology. Dr Rutkowski is an active member of the EORT^14000), and is co-author of national and international recommendations for sarcoma and melanoma. He is working very closely with national patient advocacy groups for GIST/sarcoma and melanoma and is Chairman of the Melanoma Academy in Poland. Chair of Task Group of Ministry of Health, Poland for National Oncological Strategy. Dr. Mario Mandala is associate professor of Medical oncology at University of Perugia. He received his medical degree from the Faculty of Medicine, Catholic University of Rome, Italy. He completed residency trainings in Medical Oncology and Haematology and since then he has consistently been active in medical research. He was previously Head of the Melanoma Unit, Division of Oncology, Papa Giovanni XXIII Hospital in Bergamo, Italy. In this position, he coordinated a prospective outcome research project and several clinical trials investigating new therapeutic strategies (including target therapies and immunotherapies) in melanoma and gastrointestinal cancer patients. He was recently appointed Coordinator of the Mucosal and Ocular Melanoma Section of the Italian Rare Cancers Network. Since 2011, he chaired the scientific and organizing committees of the Clinical and Translational Research Working Group of the Italian Melanoma Intergroup (IMI). From 2017 to 2019 Dr Mandala was secretary of IMI. Since 2019 Dr Mandala has been appointed as new elected president of the group Italian Melanoma Intergroup (IMI). Dr Mandala has been recently appointed chairman of the advanced systemic treatment of the EORTC melanoma group. He is full member of the European Society of Medical Oncology. He is Reviewer for several scientific journals, including Journal of Clinical Oncology, Lancet Oncology, Cancer, British Journal of Cancer, European journal of cancer, Annals of Oncology, Cancer Treatment Review, Journal of Thrombosis and Haemostasis, Thrombosis and Haemostasis, Arteriosclerosis-Thrombosis and Vascular Biology, Critical Reviews in Oncology and Haematology. He has authored more than 190 publications and his major scientific interests are clinical and translational research on melanoma, gastrointestinal cancer and thromboembolic complications in cancer patients. Since 2008, he gave major contributions in ESMO and AIOM on the management of Melanoma as well as venous thromboembolism in solid tumours.

Part 1. Pathological, molecular and immunological background of Cutaneous Malignancies.- Pathology of Melanoma and Skin Carcinomas.- Molecular Landscape Profile of Melanoma.- Molecular Landscape of Skin Carcinomas.- Immunological Features of Melanoma.- Part 2. Targeted Therapies in Skin Cancers.- Dabrafenib and Trametinib.- Vemurafenib and Cobimetinib.- Encorafenib and Binimetinib.- Vismodegib.- Sonidegib.- Part 3. Immunological Strategies in Advanced Melanoma.- Ipilimumab.- Nivolumab.- Pembrolizumab.- Talimogene Leharparepvec.- Part 4. Future of Melanoma Immunotherapy.- Perspectives of Immunotherapy in Advanced Melanoma Combinations and Sequencing.- Part 5. Immunological Therapies in Advanced Skin Carcinomas.- Avelumab.- Cemiplimab.- Perspectives of Immunotherapy in Non-Melanoma Skin Cancers.- Part 6. Mechanism of Resistance to Therapy.- Mechanisms of Resistance to Targeted Therapies in Skin Cancer.- Mechanisms of Resistance to Immunotherapy.- Part 7. Perioperative Therapy of Melanoma.- Neoadjuvant and Adjuvant Therapy in Melanoma.- Part 8. Special Techniques and Populations.- Adoptive Cell Therapy Immunological Therapies in Special Populations: HIV, Hepatitis and Organ Transplantation.- Conclusions.