Biomarkers of Hip Implant Function

Ilona Swiatkowska is an experienced researcher and editor who received her doctorate from University College London. Her academic work has centred around the local and systemic adverse effects of cobalt, chromium, and titanium in the setting of hip arthroplasty. The project was supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital (Stanmore, United Kingdom), whose research into blood cobalt and chromium levels in recipients of hip replacements directly influenced the current MHRA guidelines concerning the follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined updated laboratory reference ranges for blood and plasma titanium concentrations associated with well-functioning titanium-based hip implants.

Part I: Foundational information 1. Introduction to hip implants and biomarker testing Ilona Swiatkowska, Shiraz A. Sabah, Laura-Maria Horga and Alister J. Hart 2. Degradation of metal hip implants Andrew R. Beadling, Anne Neville and Michael G. Bryant 3. Implant metals and their potential toxicity Ilona Swiatkowska

Part II: Assessing hip implant function and risk of local and systemic adverse reactions 4. Markers of hip implant degradation: analytical considerations and clinical interpretation Pascal-Andre Vendittoli, Angela Styhler and Ilona Swiatkowska 5. Biomarkers of compromised implant fixation Reshid Berber, Benjamin Bloch, Peter James and Andrew Manktelow 6. Biomarkers of periprosthetic joint infection Marc-Olivier Kiss and Vincent Masse 7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies Ilona  Swiatkowska, Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Mathew T. Mathew and Divya Bijukumar

Part III: Translational effect of biomarker research on clinical practice 8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements Harry Hothi, Reshid Berber, Shiraz A. Sabah and Alister J. Hart