70 Years of Levothyroxine -

70 Years of Levothyroxine

George J. Kahaly (Herausgeber)

Buch | Hardcover
XVII, 129 Seiten
2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-63276-2 (ISBN)
53,49 inkl. MwSt
This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer.

When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972,  and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment.

This book is intended for healthcare professionals.

George J Kahaly, M.D., Ph.D., is a Professor of Medicine and Endocrinology / Metabolism and the Chief of the Endocrine Outpatient Clinic at the Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany. He chairs the ORPHAN JGU expert center for Graves' orbitopathy and autoimmune polyglandular syndromes and is Director of the Molecular Thyroid Research Laboratory at JGU. His interests include clinical and experimental aspects of endocrine autoimmunity, immunogenetics of thyroid and polyglandular autoimmunity, as well as cardiovascular involvement in metabolic disorders, and he has published 248 original papers and reviews in journals such as the New England Journal of Medicine, Lancet, Jama, Clinical Chemistry, the Journal of Autoimmunity, the Journal of Clinical Endocrinology and Metabolism, the Journal of Nuclear Medicine, Endocrinology, Thyroid, Endocrine Reviews, Nature Reviews and Autoimmunity Reviews .

History Of Levothyroxine.- Pharmacokinetics Of Levothyroxine.- Pharmacodynamics Of Levothyroxine .- Levothyroxine In Pregnancy.- Levothyroxine In Children.- Levothyroxine In The Elderly.- Levothyroxine And Heart.- Levothyroxine And Bone.- Levothyroxine And Cancer.- Potential Adverse Reactions Of Levothyroxine.

Erscheinungsdatum
Zusatzinfo XVII, 129 p. 37 illus., 34 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 403 g
Themenwelt Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Schlagworte endocrinology • Hypothyroidism • Metabolism • open access • Thyroid Disorders • Thyroid gland • TSH
ISBN-10 3-030-63276-8 / 3030632768
ISBN-13 978-3-030-63276-2 / 9783030632762
Zustand Neuware
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