Snake and Spider Toxins

Snake- and Spider-Venom-Derived Toxins as Lead Compounds for Drug Development.- Analytics for Bioactivity Profiling of Complex Mixtures with a Focus on Venoms.- Venom Collection from Spiders and Snakes: Voluntary and Involuntary Extractions (“Milking”) and Venom Gland Extractions.- Production and Purification of Recombinant Toxins.- RNA-Sequencing of Snake Venom Glands.- Exploring Toxin Evolution: Venom Protein Transcript Sequencing and Transcriptome-Guided High-Throughput Proteomics.- Three-Dimensional Structure Determination of Peptides using Solution Nuclear Magnetic Resonance Spectroscopy.- Determining the Structures of the Snake and Spider Toxins by X-Rays.- MALDI-TOF Mass Spectrometric Profiling of Spider Venoms.- Methods for Evaluation of a Snake Venom Derived Disintegrin in Animal Models of Human Cancer.- Cell-Based Adhesion Assays for Isolation of Snake Venom's Integrin Antagonists.- Using C. elegans to Study the Effects of Toxins in Sensory Ion Channels In Vivo.- Measurements of Cell Death Induced by Snake and Spider’s Venoms and Derived Toxins.- Using Toxins in Brain Slice Recordings.- High-Throughput Calcium Imaging Screen of Toxins’ Function in Dissociated Sensory Neurons.- Synthesizing and Expressing Native Ion Channels.