Handbook of Hematologic Malignancies (eBook)

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2020 | 2. Auflage
500 Seiten
Springer Publishing Company (Verlag)
978-0-8261-4977-0 (ISBN)
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89,99 inkl. MwSt
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This revised and updated second edition of Handbook of Hematologic Malignancies continues to be an essential and "e;go-to"e; resource for the busy hematologist, hematologic oncologist, hematopathologist, oncology advanced practice provider, oncology nurse, and trainee. Concisely organized, each chapter provides the most current, need-to-know points of diagnosis, prognosis, therapeutic management, and clinical trial opportunities for each hematological malignancy. Chapters are complete with richly illustrated figures to highlight the hematopathologic characteristics of diseases in addition to helpful tables on differential diagnosis, prognostic scoring systems, molecular profiles, and therapeutic options. A new case-based chapter concludes the handbook with clinical cases designed to test a clinician's knowledge of pathologic diagnosis and clinical presentation of diseases covered in the book. With over twenty new FDA-approved indications since publication of the first edition, including breakthroughs with CAR-T therapy, and other evidence-based treatment options for patients with hematologic disease, this book serves as quick reference to practice changing information on challenging diagnostic dilemmas, frontline and refractory treatment scenarios, and more.The subspecialty field of hematologic oncology is ever-changing and expanding with available treatment options and this second edition keeps the busy clinician abreast of recent findings and their impact on evidence-based treatment and management. Written by experienced clinicians at the world-renowned Moffitt Cancer Center in Tampa, Florida, as well as contributions from leading academicians, hematologists, and oncologists throughout the country, this unique handbook is packed with authoritative knowledge and clinical insight into all known hematologic cancers.Key Features:Includes seven new chapters covering CAR-T and novel therapeutic options including CD19 CAR-T therapy, novel cellular therapies, cytokine release syndrome, cancer associated thrombosis, and moreComprises compact and updated disease-site chapters describing new standards of care and management considerations in bullet point format with key referencesHighlights important diagnostic tools that assist with conducting key differential diagnoses and unveiling answers to diagnostic dilemmasProvides updates of potential practice-changing clinical trials and paradigm shifting treatment considerations in each disease-based chapter

Contributors


Preface


PART I: INTRODUCTION AND OVERVIEW


Chapter 1. Normal Hematopoiesis and Diagnosis Algorithms for Cytopenias and Cytoses


Chapter 2. Familial/Inherited Mutations and Risks of Hematologic Malignancies


Chapter 3. Hematopathology Diagnostic Techniques and Assays


Chapter 4. Minimal Residual Disease Assays


PART II: MYELOPROLIFERATIVE NEOPLASMS


Chapter 5. Polycythemia Vera


Chapter 6. Essential Thrombocythemia


Chapter 7. Primary Myelofibrosis


Chapter 8. Chronic Myelogenous Leukemia


Chapter 9. Chronic Neutrophilic Leukemia


Chapter 10. Systemic Mastocytosis


Chapter 11. PDGFRA/PDGFRB/FGFR1 Myeloid Neoplasms


PART III: MYELODYSPLASTIC AND BONE MARROW FAILURE SYNDROMES


Chapter 12. Myelodysplastic Syndromes


Chapter 13. Aplastic Anemia


Chapter 14. Paroxysmal Nocturnal Hemoglobinuria


PART IV: MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS


Chapter 15. Myelodysplastic/Myeloproliferative Overlap Syndromes


Chapter 16. Chronic Myelomonocytic Leukemia


PART V: ACUTE MYELOID LEUKEMIA AND RELATED SYNDROMES


Chapter 17. Acute Myeloid Leukemia


Chapter 18. Secondary AML and AML With Myelodysplasia-Related Changes


Chapter 19. Acute Promyelocytic Leukemia


Chapter 20. Blastic Plasmacytoid Dendritic Cell Neoplasm


PART VI: ACUTE LYMPHOID LEUKEMIA


Chapter 21. B-Lymphoblastic Leukemia/Lymphoma


Chapter 22. BCR-ABL1+ B-Lymphoblastic Leukemia


Chapter 23. T-Lymphoblastic Lymphoma/Leukemia  


PART VII: ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE


Chapter 24. Acute Leukemia of Ambiguous Lineage


PART VIII: MATURE T- AND NK-CELL LEUKEMIA


Chapter 25. T-Cell Prolymphocytic Leukemia


Chapter 26. T-Cell Large Granular Lymphocytic Leukemia


Chapter 27. Aggressive Natural Killer Cell Leukemia


PART IX: PLASMA CELL DISORDERS


Chapter 28. Monoclonal Gammopathy of Unknown Significance, Smoldering Myeloma, and Plasmacytomas


Chapter 29. Multiple Myeloma


Chapter 30. Waldenström’s Macroglobulinemia


Chapter 31. Immunoglobulin Light Chain Amyloidosis


PART X: HODGKIN LYMPHOMA


Chapter 32. Hodgkin Lymphoma


PART XI: NON-HODGKIN LYMPHOMA


Chapter 33. Non-Hodgkin Lymphoma Classification and Diagnostic Evaluation


PART XII: MATURE B-CELL LYMPHOMA


VERY AGGRESSIVE


Chapter 34. Burkitt Lymphoma


AGGRESSIVE


Chapter 35. Diffuse Large B-Cell Lymphoma


Chapter 36. Double Hit Lymphoma


Chapter 37. Mantle Cell Lymphoma


Chapter 38. Primary Mediastinal Large B-Cell Lymphoma


Chapter 39. Primary Central Nervous System Lymphoma


Chapter 40. HIV-Related Lymphomas


INDOLENT


Chapter 41. Follicular Lymphoma


Chapter 42. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma


Chapter 43. Hairy Cell Leukemia


Chapter 44. Marginal Zone Lymphoma


Chapter 45. Mucosa-Associated Lymphoid Tissue Lymphoma


PART XIII: MATURE T/NK-CELL LYMPHOMA


Chapter 46. Adult T-Cell Leukemia/Lymphoma


Chapter 47. Anaplastic Large Cell Lymphoma, ALK Positive


Chapter 48. Extranodal Natural Killer/T-Cell Lymphoma


Chapter 49. Mycosis Fungoides


Chapter 50. Hepatosplenic T-Cell Lymphoma


PART XIV: HISTIOCYTIC/DENDRITIC CELL NEOPLASMS


Chapter 51. Histiocytic Sarcoma, Langerhans Cell Histiocytosis, Erdheim-Chester Disease, and Rosai-Dorfman Disease


Chapter 52. Hemophagocytic Lymphohistiocytosis


PART XV: BONE MARROW TRANSPLANTATION


Chapter 53. Autologous Bone Marrow Transplantation


Chapter 54. Allogeneic Bone Marrow Transplantation


PART XVI: NEW CELLULAR IMMUNOTHERAPY


Chapter 55. CAR-T and Novel Cellular Therapeutic Options in Hematologic Malignancies


Chapter 56. CD19 CAR-T Therapy


Chapter 57. Cytokine Release Syndrome


PART XVII: EMERGENCIES IN HEMATOLOGY


Chapter 58. Cancer Associated Thrombosis


Chapter 59. Tumor Lysis Syndrome


Chapter 60. Thrombotic Microangiopathy


Chapter 61. Therapeutic Apheresis Indications


PART XVIII: NEW CLINICAL CASES IN MALIGNANT HEMATOLOGY


Chapter 62. Challenging Case Vignettes with Follow-Up Questions


Appendix: Pathology Supplement

Erscheint lt. Verlag 15.1.2021
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizinische Fachgebiete Innere Medizin Hämatologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Schlagworte cellular immunotherapy,clinical cases,differential diagnoses,hematologic malignancies,prognosis,therapeutic management
ISBN-10 0-8261-4977-4 / 0826149774
ISBN-13 978-0-8261-4977-0 / 9780826149770
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