Malignant Pleural Mesothelioma

Professor Takashi NakanoCenter for Respiratory Medicine, Osaka, Japan Professor Takashi KijimaDivision of Respiratory Medicine, Department of Internal Medicine,Hyogo College of Medicine, Hyogo, Japan

Part I Epidemiology.- 1. Recent Trends in the Global Incidence of Mesothelioma: What is the Relationship with an Asbestos Ban?.- Part II Pathogenesis.- 2. Asbestos and mesothelioma: What is recent advance in research on asbestos-induced molecular carcinogenesis?.- 3. Asbestos fiber and immunological effects: Do immunological effects play any role in asbestos-related diseases?.- 4. Biomolecular pathways in mesothelioma: What is new perspective on biomolecular research for mesothelioma?.- Part III Screening and early detection.- 5. Biomarkers for mesothelioma screening: How can we identify subjects developing mesothelioma in asbestos-exposed high-risk group?.- 6. Pleural Plaques as a predictive imaging marker for cancer screening in asbestos-exposed subjects: Can pleural plaques be a tool beyond estimating past asbestos inhalation?.- Part IV Pathology.- 7. Anatomical structure of the pleura and mesothelial cells: What arethe characteristic features?.- 8. Histologic classification of tumors of the pleura: Advances after WHO 2015 classification.- 9. Pathology of mesothelioma, subtypes and rare variants: What is the role of immunohistochemical markers in differential diagnosis?.- 10. Cytopathologic diagnosis of mesothelioma: Can we diagnose mesothelioma based on fluid cytological materials without biopsy?.- 11. Circulating tumor cells in malignant pleural mesothelioma: What is the role of liquid biopsy in clinical practice of malignant pleural mesothelioma?.- Part V Molecular Genetics.- 12. Recent advances on the pathogenesis of mesothelioma in genetics and genomics: What are novel insights into mesothelioma biology?.- 13. Genetic predisposition to mesothelioma: What are the biological mechanisms and what are the clinical characteristics of these mesotheliomas?.- 14. Frequent NF2 inactivation in mesothelioma: How can we treat mesothelioma with targeted therapies formolecular aberrations?.- Part VI Clinical Features and Management.- 15. Use of Tunneled Catheters versus Pleurodesis for Mesothelioma: When should we use one or the other, or both?.- 16. Advanced minimally invasive approach with medical thoracoscopy for mesothelioma: What are the roles in diagnosis?.- 17. Imaging evaluation of local tumor growth in malignant pleural mesothelioma: What is the role of imaging modalities in curative intent surgery for mesothelioma?.- 18. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography in malignant pleural mesothelioma: What is the role in mesothelioma detection and treatment response assessment?.- 19. Palliation in malignant pleural mesothelioma: How to manage clinical symptoms in mesothelioma.- 20. Supportive care for advanced mesothelioma: What is the role of mesothelioma nurses in clinical practice?.- Part VII Treatment; Current standard and future perspective.- 21. Antiangiogenic therapies for mesothelioma: What is the role in mesothelioma treatment?.- 22. Systemic chemotherapy for unresectable pleural mesothelioma from frontline to salvage treatment : How can we treat the patients failed to PD-1/PD-L1 inhibitors?.- 23. Biomarkers for Immune checkpoint inhibitors in mesothelioma: What are the roles of biomarkers for optimal immune therapy?.- 24. Promising investigational new drugs for mesothelioma: What is the next stage of the treatment for advanced mesothelioma?.- 25. Viral immune therapy and other virotherapies for advanced mesothelioma: Are we ready for clinical trials of viral immune therapy?.- Part VIII Radiotherapy.- 26. Impact of Radiation Therapy on Malignant Mesothelioma: Are we ready for use in clinical practice, combined with surgery or alone?.- Part IX. Surgical Intervention; Current status and future perspectives.- 27. TNM classification and the role of curative intent surgery for mesothelioma: Is the debate on extra-pleural pneumonectomy versus lung-sparing macroscopic resection over?.- 28. Surgery and adjuvant or neoadjuvant setting of radiotherapy: What is the role of radiotherapy in combination with lung-sparing surgery?.- 29. Loco-regional treatment with surgical intervention in mesothelioma: What is the role of enhancing local control approaches?.