In Vitro Approaches for the Evaluation of Drug Efficacy and Toxicity

Providing comprehensive coverage of drug bioavailability, metabolism, drug-drug interactions and toxicity, this title contains detailed information on evolving in vitro experimental systems. It covers strategic screening of drug candidates for human drug properties and outlines principles of in vitro-in vivo correlation.

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Based on the author's 20 of years of experience, this book covers the application of in vitro experimental systems in the evaluation of ADME-tox drug properties. The author dissects the reasons for clinical failure of potential drugs and discusses the importance of ADME-tox properties in clinical success. He describes current understanding of the mechanisms ADME-tox properties as a basis for in vitro assays. He highlights the importance of using human-based in vitro experimental systems to predict human in vivo outcomes. The book concludes with reviews on the state-of-the-art of in silico and genomic/proteomic experimental systems as promising approaches for the future.