Ceramide Signaling

Assembling information on the role of ceramide as a signalling molecule, this volume focuses on: mechanisms of analysis of ceramide and its biophysical properties, enzymes of ceramide metabolism and down-stream targets, the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling.

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The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.