Carbonic Anhydrase

Its Inhibitors and Activators

Claudiu T. Supuran, Andrea Scozzafava, Janet Conway (Herausgeber)

Buch | Hardcover

376 Seiten

2004
Taylor & Francis Ltd (Verlag)
978-0-415-30673-7 (ISBN)

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Provides a state-of-the-art overview of the developments in CA and CA inhibitor research and should be of interest to medicinal chemists, pharmacologists and professionals involved in novel drug design.

Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of internationally recognized experts, this authoritative edition is a leading reference for bioscientists across many disciplines, as well as novices interested in the latest developments in this complex field. An understanding of the mechanisms through which carbonic anhydrases interact with their inhibitors and activators in complex biological environments is essential in developing novel therapeutic agents for the treatment of disease.

Carbonic Anhydrases: Catalytic and Inhibition Mechanisms, Distribution and Physiological RolesC.T. SupuranAcatalytic CAs: Carbonic Anhydrase-Related ProteinsI. NishimoriMultiple Binding Modes Observed in X-Ray Structures of Carbonic Anhydrase Inhibitor Complexes and Other Systems: Consequences for Structure-Based Drug DesignJ. Antel, A. Weber, C.A. Sotriffer, G. KlebeDevelopment of Sulfonamide Carbonic Anhydrase Inhibitors (CAIs)C.T. Supuran, A. Casini, A. ScozzafavaQSAR Studies of Sulfonamide Carbonic Anhydrase InhibitorsB.W. Clare, C.T. SupuranMetal Complexes of Heterocyclic Sulfonamides as Carbonic Anhydrase InhibitorsJ. Borr?s, G. Alzuet, S. Ferrer, C.T. SupuranNonsulfonamide Carbonic Anhydrase InhibitorsM.A. Ilies, M.D. BanciuClinical Applications of the Carbonic Anhydrase Inhibitors in OphthalmologyF. Mincione, L. Menabuoni, C.T. SupuranCancer-Related Carbonic Anhydrase Isozymes and Their Inhibition S.Pastorekov?, J. PastorekRole of Carbonic Anhydrase and Its Inhibitors in Biological Science Related to Gastroenterology, Neurology and NephrologyS. Parkkila, A.K. Parkkila, J. Kivel?Carbonic Anhydrase Inhibitors in DermatologyA. Mastrolorenzo, G. Zuccati, A. Scozzafava, C.T. SupuranCarbonic Anhydrase ActivatorsM. Ilies, A. Scozzafava, C.T. Supuran

Erscheint lt. Verlag	27.5.2004
Verlagsort	London
Sprache	englisch
Gewicht	676 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
ISBN-10	0-415-30673-6 / 0415306736
ISBN-13	978-0-415-30673-7 / 9780415306737
Zustand	Neuware