Nanomedicine for Inflammatory Diseases

Dr. Lara Scheherazade Milane recently joined Burrell College of Osteopathic Medicine (Las Cruces, New Mexico) as founding faculty in the Biomedical Sciences Department and is the Director of Online Programing. Dr. Milane received her training as an NCI/NSF Nanomedicine Fellow at Northeastern University, Boston, MA. Dr. Milane has a PhD in Pharmaceutical Science with specializations in Nanomedicine and Drug Delivery Systems (Northeastern University, Boston, MA). She also received her MS in Biology and BS in Neuroscience from Northeastern University. Dr. Milane’s research interests are in cancer biology, mitochondrial medicine, and translational nanomedicine. Dr. Milane is interested in developing a library of clinically translatable targeted nanomedicine therapies for cancer treatment. She teaches in the medical program and in the post-baccalaureate program. Dr. Milane is an advocate for women in the sciences and is a pioneer for outreach. Dr. Milane has 18 peer reviewed journal publications, 3 book chapters, and 3 white papers. Dr. Mansoor Amiji is currently the University Distinguished Professor in the Department of Pharmaceutical Sciences and Co-Director of Northeastern University Nanomedicine Education and Research Consortium (NERC) at Northeastern University in Boston, MA. NERC oversees a doctoral training program in Nanomedicine Science and Technology that was co-funded by the National Institutes of Health (NIH) and the National Science Foundation (NSF). Dr. Amiji received his BS degree in pharmacy from Northeastern University in 1988 and a PhD in pharmaceutical sciences from Purdue University in 1992. His research is focused on development of biocompatible materials from natural and synthetic polymers, target-specific drug and gene delivery systems for cancer and infectious diseases, and nanotechnology applications for medical diagnosis, imaging, and therapy. His research has received over $18 million in sustained funding from the NIH, NSF, private foundations, and the pharmaceutical/biotech industries. Dr. Amiji teaches in the professional pharmacy program and in the graduate programs of Pharmaceutical Science, Biotechnology, and Nanomedicine. He has published six books and over 200 book chapters, peer-reviewed articles, and conference proceedings. He has received a number of honors and awards including the Nano Science and Technology Institute’s Award for Outstanding Contributions towards the Advancement of Nanotechnology, Microtechnology, and Biotechnology, American Association of Pharmaceutical Scientists (AAPS) Meritorious Manuscript Award, Controlled Release Society’s (CRS) Nagai Award, and the AAPS and CRS Fellowships.

Part I • Introduction: Introduction



to Inflammatory Disease,



Nanomedicine, and



Translational Nanomedicine

1 • FUNDAMENTALS OF IMMUNOLOGY



AND INFLAMMATION



2 • PRINCIPLES OF NANOMEDICINE



3 • NANOTOXICITY



4 • TRANSLATIONAL NANOMEDICINE



Part II • Introduction: Primary



Inflammatory Disease

5.1 • BIOLOGY AND CLINICAL TREATMENT



OF INFLAMMATORY BOWEL DISEASE



5.2 • NANOTHERAPEUTICS FOR



INFLAMMATORY BOWEL DISEASE



5.3 • BRIDGING THE GAP BETWEEN



THE BENCH AND THE CLINIC:



INFLAMMATORY BOWEL DISEASE



6.1 • THE BIOLOGY AND CLINICAL



TREATMENT OF MULTIPLE SCLEROSIS



6.2 • NANOTHERAPEUTICS FOR MULTIPLE



SCLEROSIS



6.3 • BRIDGING THE GAP BETWEEN THE



BENCH AND THE CLINIC



7.1 • THE BIOLOGY AND CLINICAL



TREATMENT OF ASTHMA



7.2 • NANOTHERAPEUTICS FOR ASTHMA



7.3 • BRIDGING THE GAP BETWEEN THE



BENCH AND THE CLINIC: ASTHMA



Part III • Introduction:



The Emerging Role



of Inflammation



in Common Diseases

8 • NEURODEGENERATIVE DISEASE



9 • CANCER



10 • DIABETES



11 • CONCLUDING REMARKS