Lung Stem Cells in Development, Health and Disease

Marko Z. Nikolić is a UKRI (UK Research and Innovation) Innovation/Rutherford Fellow at University College London (London, UK) as part of the UK Regenerative Medicine Platform. He set up an independent research group at University College London. He is an Honorary Consultant in Respiratory Medicine at Royal Papworth (Cambridge, UK), Cambridge University Hospitals and University College London Hospitals Foundation Trusts. Brigid L.M. Hogan’s lab was among the first to use genetically engineered mice to identify and study stem and progenitor cells in the adult lung and their role in tissue maintenance and repair after injury. Her lab also developed some of the first lung organoids. From 2002 to 2019, Brigid was George Barth Geller Professor and Chair of the Dept of Cell Biology at Duke University (Durham, NC, USA). She is a member of the National Academy of Medicine and the National Academy of Sciences in the USA and a Fellow of the Royal Society of London.

Lung development; Alveolar stem cells in lung development and regrowth; Lung blood and lymphatic vascular development; Neuroendocrine cells in lung development and disease; Adult mouse and human airway epithelial basal stem cells; Stem cells of submucosal glands: their function as tissue stem cells and a reserve population for airway repair; Adult mouse intralobar airway stem cells; Evidence for the involvement of lipofibroblasts, airway smooth muscle cells and FGF10 signalling in lung repair; Respiratory bronchioles: a unique structure in the human lung; Alveolar epithelial stem cells in homeostasis and repair; Mesenchymal cells, immune cells and the lung stem cell niche; Endothelial cells in the lung; The Human Lung Cell Atlas: a transformational resource for cells of the respiratory system; Lung organoids: powerful tools for studying lung stem cells and diseases; Induced pluripotent stem cells for generating lung airway stem cells and modelling respiratory disease; Induced pluripotent stem cells for generating lung alveolar epithelial cells and modelling respiratory disease; Three-dimensional tissue-based models for translational lung stem cell research: precision-cut lung slices; The use of pre-conditioning and novel assays in the development of protocols for transplantation of lung progenitors; Lung tissue bioengineering for transplantation and modelling of development, disease and regeneration; Ferret respiratory disease models for the study of lung stem cells; Epithelial stem cells at the intersection of tissue regeneration and pulmonary fibrosis; Lung stem cells and therapy for cystic fibrosis; The role of altered stem cell function in airway and alveolar repair and remodelling in COPD; Stem cells and lung cancer; Progress and potential of mesenchymal stromal cell therapy in acute respiratory distress syndrome; The next 10 years in lung stem cell research