Liver Transplantation

JAMES NEUBERGER, DM, FRCP is Consultant Physician in the Liver Unit, Birmingham, UK. A previous President of the British Association for the Study of the Liver, he has over 35 years of liver transplantation and disease experience and has edited five books on liver disease and liver transplantation and published extensively in liver disease and transplantation.

JAMES FERGUSON, MD, FRCPE is Consultant Hepatologist at the Queen Elizabeth Hospital in Birmingham, UK. He has extensive experience in managing patients with liver disease and in liver transplantation.

PHILIP N. NEWSOME, PHD, FRCPE is Professor of Experimental Hepatology and Honorary Consultant Hepatologist, Director of Research and Knowledge Transfer for the College of Medical & Dental Sciences and Director of the Centre for Liver and Gastrointestinal Research in the University of Birmingham, UK. Currently Secretary General of the European Association for the Study of the Liver, he continues to research in all aspects of liver disease and stem cell therapy.

MICHAEL RONAN LUCEY, MD, FRCPI is Chief of the Division of Gastroenterology and Hepatology at the University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. A past President of the American Society of Transplantation, he continues to publish widely in the field of liver disease and liver transplantation.

List of Contributors


Foreword to the first edition


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Foreword to the second edition


Preface


Abbreviations


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PART 1 When to Refer a Patient for Liver Transplantation


1 Overview on organ donation and liver transplantation


Michael Ronan Lucey


2 Predicting Outcomes and Use and Abuse of Prognostic Models


Moira B. Hilscher and Patrick S. Kamath


PART 2 Selection, Assessment and Management on the List


3 Assessment of the potential transplant recipient


Michael Volk


4 Frailty and pre-habilitation


Armstrong MJ, Lai JC


5 Alcohol use (excluding alcohol related liver disease), Tobacco, Marijuana and Illicit Drugs


John P. Rice


6 The Role of the Psychiatric Consultant in the Selection, Assessment and Management of Liver Transplant Patients


RM Weinrieb


7 When Liver Transplant Patients do not Adhere to Therapeutic Plans


Kerry Webb and Rowena Jones


8 Liver transplant assessment for young people : addressing the needs of young people with liver disease


M Samyn, J Day


9 Assessment and Management of the patient with Hepatitis C


Emma L. Hathorn and David J. Mutimer


10 MANAGEMENT OF HBV INFECTION PRE-TRANSPLANTATION


Bruno ROCHE, Didier SAMUEL


11 Transplantation For The Management Of Malignancy


Adiba I. Azad, Julie K. Heimbach and Gregory J. Gores


12 Assessment and management of the liver transplant candidate with acute-on-chronic liver failure


Giovanni Perricone and Rajiv Jalan


13 Assessment and Management of the transplant candidate with alcohol-associated liver disease


Stephanie Faure, Magda Meszaros, Lucy Meunier, Helene Donnadieu-Rigole, Georges-Philippe Pageaux


14 NAFLD as an indication for liver transplantation


P. Horn, P.N. Newsome


15 Consent


Christopher J.E. Watso


16 Prehabilitation and General Management


Matt Armstrong and F. Williams


17 Removal of Patients from the Liver Transplant Waiting List


John O'Grady


18 Palliative Care and Liver Transplantation


Mina Rakoski and Puneeta Tandon


PART 3 Transplantation for Acute Liver Failure


19 Assessment of the Patient with Acute Liver Failure


Ashley Barnabas and John O'Grady


20 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation


Robert J. Fontana


PART 4 Donation and Allocation


21 Ethical and Legal Aspects of Organ Donation


Jessica Mellinger


22 Liver allocation, including Principles of organ allocation


Parita Patel and Michael Charlton


23 Living Donor Liver Transplant (LDLT) in Children


Adebowale A. Adeyemi, Elizabeth B. Rand, Kim M Olthoff


24 Living liver donation in adults


Mohamed Rela and Ashwin Rammohan


25 Deceased Liver Donors: Standard and Expanded Criteria


Shareef Syed and Sandy Feng


26 Donor Transmitted Disease


James Neuberger


27 LIVER DONATION AND PRESERVATION


Navneet Tiwari, Hynek Mergental


28 Liver Retrieval and Preservation


Carlo DL Ceresa, Brian R Davidson, Peter J Friend and Rutger J Ploeg


29 Alternatives to Whole Graft Liver Transplantation


Paolo Muiesan, Alessandro Parente, Hector Vilca-Melendez


30 Surgical aspects of deceased donor transplantation


Amit Nair, K.V Narayanan Menon, Cristiano Quintini and Charles Miller


PART 5 Care of the Liver Transplant Recipient


31 Outcomes after liver transplantation


James Neuberger


32 Out-patient follow-up of liver transplant recipients


Amardeep Khanna & James Ferguson


33 Medication adherence


Maureen Whitsett, Josh Levitsky


34 Transitional Care


Fiona Thompson


35 Managing the liver transplant recipient with abnormal liver blood tests


Joanna A Leithead


36 The Immune System in Liver Transplantation: Rejection vs. Tolerance


Palak J. Trivedi and Nick D. Jones


37 Immunosuppressive Medications - Liver Transplantation


Mitchell T, MacQuillan G


38 Immunosuppression in Liver Transplantation


Nicholas Lim and John R. Lake


39 : Patterns of Liver Allograft Rejection


G. W. McCaughan, K. Liu, A. Majumdar, P. Bertolino, D.G. Bowen, S. I. Strasser


40 De novo autoimmune hepatitis


James Neuberger


41 Managing rejection


Neil Halliday & Douglas Thorburn


42 Withdrawal of Immunosuppression after liver transplantation


Luca Toti, Tommaso Maria Manzia, Francesca Blasi, Giuseppe Tisone.


43 Liver Transplant Pathology


Owen L Cain and Stefan G Hubscher


44 Care of the Liver Transplant Recipient: Management of Renal Function


Andres F. Carrion, Paul Martin


45 Managing Cardiovascular Risk in the Liver Transplant Recipient


Manhal Izzy and Kymberly D. Watt


46 Bone Disease in Liver Transplantation


John Ayuk


47 Diagnosis and Management of Recurrent Autoimmune Liver Disease


Fernanda Q Onofrio, Nazia Selzner, Gideon M Hirschfield


48 NAFLD and NASH in the patient after liver transplantation


P. Horn, P.N. Newsome


49 Recurrent Metabolic Diseases


James Neuberge


50 Treatment of Hepatitis C in the Transplant Setting


Jeffrey Kahn and Norah A. Terrault


51 MANAGEMENT OF HBV INFECTION POST-TRANSPLANTATION


Bruno ROCHE, Didier SAMUEL


52 Antimicrobial prophylaxis following liver transplantation


Michael J Williams, Peter C Hayes


53 Cytomegalovirus and the liver transplant recipient


James Ferguson


54 Post-liver transplant infections


Miruna David, Ahmed El-Sharkawi


55 De novo malignancies after liver transplantation


Simone I Strasser, Ken Liu, Avik Majumdar, Geoffrey W McCaughan


56 Post-transplant lymphoproliferative disorders (PTLD).


Jose I. Herrero


57 Quality of life and Employment after liver transplantation


Santiago Tome, Esteban Otero, and Michael Lucey


58 Sexual function, fertility and pregnancy in liver disease and after liver transplantation


Patrizia Burra, Salvatore Stefano Sciarrone, Patrizio Bo


59 Common Drug Interactions


Amanda Smith


60 Immunization and Liver Transplantation


Erin Spengler


Postscript


Index