Sarcoidosis

Donald N Mitchell MD FRCP Hon Consultant Physician Royal Brompton and University College Hospitals London, UK David R Moller MD Professor of Medicine and Director Sarcoidosis Clinic and Research Program Department of Medicine The Johns Hopkins University School of Medicine Baltimore, Maryland, USA Stephen G Spiro BSc MD FRCP Professor of Respiratory Medicine and Honorary Consultant Physician University College London and The Royal Brompton Hospital London, UK Athol Wells MBChB MD FRACP FRCP FRCR Professor of Respiratory Medicine and Head of Interstitial Lung Disease Unit The Royal Brompton Hospital London, UK

Historical survey. Definition. Epidemiology Aetiology. Pathology. Immunology. Genetics. The radiology of the lungs and the pleura. Intervention and radiological procedures. Lung function. Endoscopy. DEXA scanning. Nuclear medicine imaging. ECG; Holter monitoring; exercise tests. The heart, pericardium, large and small vessels. The upper respiratory tract. Asthma/irritable airways. Pulmonary fibrosis. The liver and gastrointestinal tract. The spleen, blood and bone marrow. The nervous system. The kidneys and calcium metabolism. Psychiatric aspects. Sarcoidosis of the skin. Ocular changes. Bones, joints and skeletal muscles. Superficial lymphadenopathy. The endocrine glands. Sarcoid/HIV and AIDS. Sarcoid/relationship to neoplasm/chemotherapy [including isolated breast lesions]. Sarcoid/antibody deficiency syndromes. Concomitant or associated disorders. Pulmonary and extrapulmonary involvement by sarcoidosis in childhood. Diagnosis of sarcoidosis: history, physical examination, presumptive diagnosis without biopsy, sources of biopsy material, utilisation of investigations and imaging. Treatment of sarcoidosis:. Surgical investigation and management. Pulmonary/cardiac transplantation. Physiotherapy in sarcoidosis. Rehabilitation. Immunisation/vaccination. Future progress in investigations and management.