Dopamine Receptors and Transporters

Anita Sidhu, Georgetown University, Medical Center Washington, D.C. Marc Laruelle, Columbia University, College of Physicians and Surgeons and New York State Psychiatric Institute. Philippe Vernier, Institute of Neurobiology, Alfred Fessard Gif-sur-Yvette, France.

Part 1: Origin and evolution of dopamine receptors and transporters in vertebrates; structure of mammalian D1 and D5 dopamine receptors and their function and regulation in cells. Part 2: Organization of dopamine systems in the mammalian brain;interactions of DA receptor subtypes with other receptor systems. Part 3: overview of schizophrenia; dopaminergic systems in Parkinson's disease. Part 4: dopamine transporters - structure-activity relationships and regulation in neurones; dopaminetransporters - pharmacology and invovlement in neurolopsychiatric diseases. Part 5: imaging dopamine transmission in schizophrenia and other major psychiatric disorders; imaging dopamine transporters in Parkinson's disease and other movement disorders.