Nanomaterials in Biomedical Application and Biosensors (NAP-2019) (eBook)
XVII, 271 Seiten
Springer Singapore (Verlag)
978-981-15-3996-1 (ISBN)
This book covers novel and innovative technologies used in development, modeling, chemical/physical investigation and biomedical (in-vitro and in-vivo) trials of nanomaterials and nanocomposites. Novel methods for nanoparticle development and manufacturing are presented, as well as their safety and promising applications. In addition, the book highlights new frontiers in the use of metal / metal oxide nanoparticles, hierarchical nanostructures and organic coatings as sensors for detecting gases, inorganic and organic materials, including biosensors for bacteria and cancers. Organic nanoparticle composites for medical applications (tissue engineering, tissue replacement, regeneration, etc.), including hydroxyapatite NPs, are also covered, together with related in-vitro and preclinical investigations. In closing, the book shares recent findings on orthopedic and dental implant coatings using nanoparticles, their biological efficacy and safety.
This book covers novel and innovative technologies used in development, modeling, chemical/physical investigation and biomedical (in-vitro and in-vivo) trials of nanomaterials and nanocomposites. Novel methods for nanoparticle development and manufacturing are presented, as well as their safety and promising applications. In addition, the book highlights new frontiers in the use of metal / metal oxide nanoparticles, hierarchical nanostructures and organic coatings as sensors for detecting gases, inorganic and organic materials, including biosensors for bacteria and cancers. Organic nanoparticle composites for medical applications (tissue engineering, tissue replacement, regeneration, etc.), including hydroxyapatite NPs, are also covered, together with related in-vitro and preclinical investigations. In closing, the book shares recent findings on orthopedic and dental implant coatings using nanoparticles, their biological efficacy and safety.
Preface 6
Contents 7
Contributors 11
1 Bacterial Cellulose/Hydroxyapatite Printed Scaffolds for Bone Engineering 18
1.1 Introduction 19
1.2 Method and Materials 19
1.3 Results and Discussion 20
1.4 Conclusion 21
References 22
2 Delivery of Probiotic to Microbiome by Layer-by-Layer Encapsulation 25
2.1 Introduction 25
2.2 Materials and Methods 27
2.2.1 Preparation of Bacteria for Microencapsulation 27
2.2.2 Preparation of Encapsulated Probiotics 27
2.2.3 Quantification of Viable Bacteria in Capsules 28
2.2.4 Determination of Resistance of Encapsulated Bacteria to Conditions that Mimic Human Gastrointestinal Tract 28
2.2.5 Statistical Analysis 29
2.3 Results and Discussion 29
2.4 Conclusion 33
References 34
3 Modernization of the Preservative Solution for Red Blood Cells by Magnetite Nanoparticles (ICNB) 35
3.1 Introduction 35
3.2 Materials and Methods 38
3.3 Results and Discussion 41
3.4 Conclusions 47
References 48
4 Application of Infrared Spectroscopy to Study the Effect of Magnetite Nanoparticles (ICNB) on Molecular Structure of the Membranes of Preserved RBCs 50
4.1 Introduction 51
4.2 Materials and Methods 53
4.2.1 Materials 53
4.2.2 Objects of Research 56
4.3 Results and Discussion 57
4.4 Conclusions 64
References 64
5 Morphological Changes in Gram-Negative Microorganisms Treated with Silver and Copper Nanoparticles 66
5.1 Introduction 66
5.2 Materials and Methods 67
5.2.1 Materials 67
5.2.2 Synthesis of Cu NPs and Ag NPs 67
5.2.3 Cu NPs and Ag NPs Characterization 68
5.2.4 Antibacterial Assessment 68
5.2.5 Statistic 69
5.3 Results 69
5.4 Discussion 71
5.5 Conclusion 72
References 72
6 Regularities of Obtaining Metal-Filled Polymer Composites 73
6.1 Introduction 73
6.2 Regularity of Polypropylene Copper Plating 75
6.3 Conclusions 79
References 79
7 Synthesis, Characterization and Antibacterial Activity of Hydroxyapatite Composite Materials Loaded with ZnO Nanoparticles 81
7.1 Introduction 81
7.2 Experiment Details 82
7.2.1 Synthesis of Hydroxyapatite Nanoparticles 83
7.2.2 ZnO Nanoparticles Synthesis 83
7.2.3 Antibacterial Properties 84
7.2.4 Statistic 84
7.3 Results and Discussion 85
7.4 Conclusions 88
References 88
8 Plasma Electrolytic Oxidation of TiZr Alloy in ZnONPs-Contained Solution: Structural and Biological Assessment 89
8.1 Introduction 90
8.2 Materials and Methods 90
8.2.1 Materials 90
8.2.2 Synthesis of ZnO Nanocrystals 91
8.2.3 Plasma Electrolytic Oxidation 91
8.2.4 SEM 91
8.2.5 Contact Angle Measurement 92
8.2.6 SBF 92
8.2.7 In Vitro Experiment 92
8.3 Results 93
8.3.1 SEM, EDX and Contact Angle 93
8.3.2 SBF Test 94
8.3.3 Cell Culture 95
8.3.4 Bacteria Adhesion Test 95
8.4 Conclusions 96
References 96
9 Plasma Electrolytic Oxidation of the Titanium-Zirconium Alloy (Zr60Nb21Ti19) for Dental Implant 97
9.1 Introduction 98
9.2 Materials and Methods 99
9.2.1 Materials 99
9.2.2 Plasma Electrolytic Oxidation 99
9.2.3 SEM, EDX and Contact Angle Measurements 100
9.2.4 SBF 100
9.2.5 Bacteria Adhesion Test 100
9.2.6 Cell Culture 101
9.2.7 Statistics 101
9.3 Results 102
9.3.1 SEM with EDX 102
9.3.2 SBF 103
9.3.3 Cell Culture 103
9.3.4 Bacteria Adhesion Test 104
9.4 Conclusion 105
References 106
10 Nanostructured Hemostatic Sponges Made from Chitosan: Structural and Biological Evaluation 108
10.1 Introduction 108
10.2 Materials and Methods 110
10.2.1 Hemostatic Agents Synthesis 110
10.2.2 FT-IR Analysis 110
10.2.3 Porosity and Density 110
10.2.4 Swelling Properties 111
10.2.5 Water Vapor Transmission Rate 111
10.2.6 Antioxidant Activity 112
10.2.7 SEM Analysis 112
10.2.8 Time-Depending Antimicrobial Assay 113
10.2.9 Blood Clotting Tests 114
10.2.10 Scanning Electron Microscopy (SEM) 114
10.2.11 Cell Culture 114
10.2.12 Statistics 115
10.3 Results and Discussion 115
10.3.1 FT-IR Analysis 115
10.3.2 Morphology and Elemental Composition Study 116
10.3.3 Swelling Properties 117
10.3.4 Porosity and Density Study 118
10.3.5 Antioxidant Properties Study 118
10.3.6 Water Vapor Transmission Rate (WVTR) 119
10.3.7 Time-Depending Antimicrobial Assay 119
10.3.8 Blood-Clotting Experiment and Scanning Electron Microscopy (SEM) Analysis 121
10.3.9 Cell Toxicity Experiment 121
10.4 Conclusions 122
References 123
11 Composite Ultrafiltration Membrane Incorporated with Dispersed Oxide Nanoparticles 124
11.1 Introduction 124
11.2 Experiment Details 125
11.2.1 Membrane Modifying 125
11.2.2 Membrane Testing 126
11.3 Results and Discussion 127
11.3.1 Morphology of Membranes 127
11.3.2 Water Filtration. Secondary Active Layer 129
11.3.3 Filtration of Sugar Beet Juice 130
11.4 Conclusions 131
References 132
12 The Laser-Induced Coagulation Method of Biological Tissues 133
12.1 Introduction 133
12.2 Research Methodology 134
12.3 Results and Discussion 136
12.4 Conclusions 138
References 139
13 Fullerene C60-Containing Hydroxyapatite/Polymer Polyelectrolyte Composite for Dental Applications 140
13.1 Introduction 141
13.2 Experiment Details 142
13.2.1 Materials 142
13.2.2 Composite Material Obtaining 142
13.2.3 Analytical Methods 143
13.3 Results and Discussion 144
13.4 Conclusions 147
References 147
14 Graphene Oxide Influences on Mechanical Properties and Drug Release Ability of Hydroxyapatite Based Composite Material 149
14.1 Introduction 150
14.2 Experiment Details 150
14.2.1 Materials 150
14.2.2 Material Preparation 151
14.2.3 Analytical Methods 151
14.3 Results and Discussion 152
14.4 Conclusions 158
References 159
15 Effect of Surface Modification of Sputtered Ta2O5 Magnetron Ceramic Coatings on the Functional Properties of Antigen-Presenting Cells In Vitro Tests 160
15.1 Introduction 160
15.2 Materials and Methods 161
15.3 Results and Discussion 163
15.4 Conclusions 166
References 167
16 Features of Bacterial Cellulose Hydroxyapatite Nanocomposites Obtained by Two Different Techniques 169
16.1 Introduction 169
16.2 Materials and Methods 170
16.2.1 Synthesis of Gel Film BC 170
16.2.2 Development of Composite BC/HA 171
16.2.3 Scanning Electron Microscopy (SEM) Studies 171
16.2.4 The Study of the Strength of Films of Bacterial Cellulose and Composite BC/HA 172
16.2.5 Statistical Analysis 172
16.3 Results and Discussion 172
16.4 Conclusion 174
References 174
17 Quality Parameters of Cellulose–Chitosan Based Edible Films for Probiotic Entrapment 176
17.1 Introduction 176
17.2 Materials and Methods 177
17.3 Results and Discussion 179
17.4 Conclusion 183
References 183
18 Synthesis of Silver Nanoparticles and Therapeutic Films for Ophthalmology Based on Them 185
18.1 Introduction 185
18.2 Material and Research Methods 187
18.3 Results and Discussion 187
18.3.1 Synthesis and Optical Properties of Ag NPs 187
18.3.2 Ultrastructure of the Cornea in the Area of Reparative Regeneration of ACE at the Border with the Performed Stromectomy and with the Subsequent Application of the Film with Decamethoxin 192
18.4 Conclusions 192
References 193
19 A Hg (II) Fluorescent Sensor Based-on Bodipy Synthesized by Using Knorr Pyrrole 195
19.1 Introduction 195
19.2 Experiment Details 196
19.2.1 The Synthesis of Bodipy Including Alkly-Chloro (Compound 1) 197
19.2.2 The Synthesis of 8-(azidomethyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a, 4a-diaza-s-indacene (Compound 2) 197
19.2.3 Synthesis of N1, N3-di (Prop-2-yn-1-yl) Isophthalamide (Compound 3) 198
19.2.4 The Synthesis of Bodipy 199
19.3 Results and Discussion 199
19.4 Conclusions 202
References 203
20 Resistance of Hall Sensors Based on Graphene to Neutron Radiation 204
20.1 Introduction 204
20.2 Experiment Details 206
20.2.1 Hall Sensors Samples 206
20.2.2 Sensor Characteristics Measurement Methods 207
20.2.3 Temperature Testing for Samples Selection 208
20.2.4 In-Situ Investigations of Irradiation Stability 210
20.3 Results and Discussion 211
20.4 Conclusion 212
References 213
21 Adhesive and Barrier Sublayers for Metal Nanofilms Active Elements of Hall Sensors 215
21.1 Introduction 215
21.2 Experiment Details 217
21.2.1 Samples 217
21.2.2 Measurement Technique 218
21.3 Results and Discussion 219
21.4 Conclusions 222
References 222
22 Morphology and Luminescence Properties of Cellulose-CNT-BiPO4:Pr3+ Composites 224
22.1 Introduction 224
22.2 Experiment Details 225
22.3 Results and Discussion 226
22.4 Conclusions 229
References 229
23 Time Dependence of X-Ray Luminescence from Yttrium Oxide Nanoceramics 231
23.1 Introduction 231
23.2 Experiment 232
23.3 Results and Discussions 234
23.4 Conclusions 238
References 239
24 Electrochemical Formation of ‘Synthetic Receptors’ Based on Conducting Polymers 240
24.1 Introduction 241
24.2 Synthesis of Conducting Polymers 241
24.2.1 Synthesis of Conducting Polymers 241
24.2.2 Some Chemical and Physical Properties of Conducting Polymers 243
24.3 Conducting Polymers for Biosensor Design 243
24.4 Conclusions 244
References 245
25 Optical Immunosensor Based on Photoluminescent TiO2 Nanostructures for Determination of Bovine Leucosis Proteins. Model of Interaction Mechanism 247
25.1 Introduction 247
25.2 Experiment Details 249
25.3 Results and Discussion 249
25.3.1 Mechanism of Interaction Between TiO2 and Proteins 252
25.4 Conclusions 255
References 256
26 Electrical and Photoelectric Properties of Iron/Chromium Oxide Nanolayers Composite Structures 258
26.1 Introduction 259
26.2 Experiment Details 260
26.2.1 Materials 260
26.2.2 Methods 260
26.3 Results and Discussion 261
26.3.1 Surface Electronic Structure Characterization 261
26.3.2 Kinetics and Spectral Distribution of the Surface Photovoltage 263
26.3.3 Impedance Spectroscopy 265
26.4 Conclusions 266
References 266
Subject Index 268
Erscheint lt. Verlag | 19.4.2020 |
---|---|
Reihe/Serie | Springer Proceedings in Physics | Springer Proceedings in Physics |
Zusatzinfo | XVII, 271 p. 126 illus., 76 illus. in color. |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Pflege |
Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie | |
Naturwissenschaften ► Biologie | |
Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik | |
Technik ► Maschinenbau | |
Technik ► Medizintechnik | |
Schlagworte | Antibacterial Nanoparticles • biomedical devices • Cancer Detection • Cell-Nanoparticle Interaction • Dental Implants • Fluorescent sensors • Hydroxyapatite-NPs • Metal Oxide Nanoparticles • Nanocomposites • Nanoparticle In-Vivo Trials • Nanoparticle Safety |
ISBN-10 | 981-15-3996-0 / 9811539960 |
ISBN-13 | 978-981-15-3996-1 / 9789811539961 |
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