Next Generation Kinase Inhibitors
Springer International Publishing (Verlag)
978-3-030-48282-4 (ISBN)
Paul Shapiro has a long-standing interest in protein kinases and their role in regulating cellular functions during disease. Specific areas focus on the discovery and development of function-selective mitogen-activated protein (MAP) kinase inhibitors with the goal of mitigating cancer cell proliferation and inflammation-induced lung injury associated with respiratory diseases. He received a Bachelor of Science degree from the University of Wisconsin-Madison and his doctorate in molecular physiology and biophysics from the University of Vermont. Dr. Shapiro completed post-doctoral training in the Department of Chemistry and Biochemistry at the University of Colorado-Boulder and is currently a professor of Pharmaceutical Sciences at the University of Maryland School of Pharmacy.
lt;p>Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors. [Paul Shapiro et al.]
Chapter 2: Overview of Current Type I/II Kinase Inhibitors. [Zheng Zhao, Philip E. Bourne]
Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors. [Paul Shapiro et al]
Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins. [Paul Shapiro et al.]
Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches [Yu et al.]
Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition [Rachel Sammons and Kevin Dalby]
Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases (Helton et al.)
Chapter 8: Novel peptide-based inhibitors of protein kinases [Justin Holub]
Erscheinungsdatum | 16.07.2020 |
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Zusatzinfo | XII, 217 p. 59 illus., 56 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Maße | 155 x 235 mm |
Gewicht | 505 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
Medizin / Pharmazie ► Studium | |
Schlagworte | ATP binding sites • catalytic sites • dysregulated kinase activity • Kinase Inhibitors • kinase signaling pathways • phosphorylation |
ISBN-10 | 3-030-48282-0 / 3030482820 |
ISBN-13 | 978-3-030-48282-4 / 9783030482824 |
Zustand | Neuware |
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