Coenzyme Q in Aging

Guillermo López Lluch Graduated in Biology at the University of Córdoba, Spain in July, 1992. PhD (Biology) at the University of Cordoba in July, 1997. Professor at the Pablo de Olavide, Seville, from 1998 starting as Assistant professor and obtaining a position as Lecturer/Reader in May 2003. Between June, 1999 and October, 2000 postdoctoral student granted with a Marie Curie Fellowship from the European Commission at the Department of Molecular Medicine (Rayne Institute), University College of London working on the biology of neutrophils under the supervision of Dr. Anthony W. Segal and Dr. Lodewijk V. Dekker. From October, 2018, Full Professor in the Area of Cell Biology of the Department of Physiology, Anatomy and Cell Biology of this University. Further, Associate Researcher at the Andalusian Centre for Developmental Biology (CSIC-UPO-JA) at the same University. Current research field: metabolic and antioxidant regulation during aging. The importance of metabolism and mitochondrial physiology is clear. Many prolongevity effectors regulate mitochondrial activity and turnover and affect endogenous antioxidant activities that seems to be coordinated with metabolism. The role of coenzyme Q and its enzymatic-dependent activities is important in this regulation and in the progression of aging and is the current focus of research. This research has produced 90 international publications, around 20 book chapters and more than 200 contributions to congresses including invited conferences.

Preface.- Part 1 Basics on coenzyme Q.- Introduction. The current coenzyme Q science and knowledge.- Molecular structure, biosynthesis, and distribution of coenzyme Q.- Coenzyme Q function in mitochondria.- Extramitochondrial coenzyme Q₁₀ in aging.-  Regulation of the synthesis of Coenzyme Q₁₀.- Part 2 Coenzyme Q in aging studies.- Coenzyme Q and aging in C. elegans.- Coenzyme Q and aging in the fruit fly Drosophila melanogaster.- The aging process and coenzyme Q: clk-1 mouse models.-  Reduced coenzyme Q₁₀ decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions.- Part 3 Age-related diseases and coenzyme Q.- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging.- Coenzyme Q₁₀ and metabolic syndrome.- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases.- Immunosenescence and CoQ₁₀.- Coenzyme Q₁₀ in fertility and reproduction.- Part 4 Prolongevity effectors and Coenzyme Q.- Calorie restriction, longevity and coenzyme Q.- Age dependent changes of coenzyme Q levels and its induction in experimental systems.- Effects of coenzyme Q₁₀ supplementation on elderly people.- Index.