Molecular Biochemical Aspects of Cancer

Prof. Undurti N. Das is an M.D. in Internal Medicine from Osmania Medical College, Hyderabad, India; Doctor of Science (D.Sc.) from Mangalore University, India, a Fellow of the National Academy of Medical Sciences, India, a fellow of the Royal Society of Chemistry and Shanti Swaroop Bhatnagar prize awardee. Apart from clinical work, he is researching the role of polyunsaturated fatty acids, cytokines, nitric oxide, free radicals, and anti-oxidants in cancer, inflammation, metabolic syndrome, schizophrenia and tropical diseases. His current interests include cancer, molecular biological aspects of diabetes mellitus, hypertension, cardiovascular diseases, autoimmune diseases and metabolic syndrome. Dr. Das was formerly scientist at Efamol Research Institute, Kentville, Canada; Professor of Medicine at Nizam’s Institute of Medical Sciences, Hyderabad, India and Research Professor of Surgery and Nutrition at SUNY Upstate Medical University, Syracuse, USA. At present, he is the Chairman and Research Director of UND Life Sciences LLC, Battle Ground, WA, USA and Chairman and Professor of Medicine at GVP Hospital and Medical College, Visakhapatnam, India and Director of BioScience Research Centre, GVP College of Engineering campus, Visakhapatnam, India serves as a consultant to both Indian and USA based biotech and pharmaceutical companies. Undurti Das is the Editor-in-Chief of the international journal: Lipids in Health and Disease; Academic Editor of Medicine and Review Editor of Nutrition journals and serves on the editorial board of another 10 international journals. Dr. Das has authored more than 500 international publications, wrote 4 books and has been awarded 6 USA patents. He is now developing lipid-based drugs for cancer, diabetes mellitus, lupus and rheumatoid arthritis and sepsis.

Chapter 1: Introduction to genes, oncogenes, and anti-oncogenesChapter 2: Introduction to free radicals (including nitric oxide), antioxidants, lipid peroxidation and their effects on cell proliferationChapter 3: Immune system, inflammation and essential fatty acids and their metabolites in cancerChapter 4: PUFAs and their metabolites in carcinogenesisChapter 5: Molecular mechanism of anti-cancer action of PUFAs with particular reference to GLA in gliomaChapter 6: Bioactive lipids (BAL)-based therapeutic approach to cancer that enhances anti-tumor action and ameliorates cytokine release syndrome of immune check point inhibitorsChapter 7: A new therapeutic strategy to treat cancer based on bioactive lipids (BAL)Index